分裂型人格特质、注意力缺陷多动障碍与多巴胺基因
Schizotypy, attention deficit hyperactivity disorder, and dopamine genes.
作者信息
Ettinger Ulrich, Joober Ridha, DE Guzman Rosherrie, O'driscoll Gillian A
机构信息
Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK.
出版信息
Psychiatry Clin Neurosci. 2006 Dec;60(6):764-7. doi: 10.1111/j.1440-1819.2006.01594.x.
Previous research has suggested that there may be overlap between schizophrenia and attention-deficit hyperactivity disorder (ADHD). The relationship between schizotypal personality traits, ADHD features and polymorphisms was evaluated in dopamine-related genes. Thirty-one healthy, Caucasian men completed the Rust Inventory of Schizotypal Cognitions (RISC) and the ADHD Self-Report Scale (ASRS). Catechol-O-methyltransferase (COMT) Val158Met, dopamine receptors of the D3 type (DRD3) Ser9Gly, DRD4 variable number of tandem repeats (VNTR), and SLC6A3 VNTR polymorphisms were analyzed. RISC score was correlated with ASRS score (r = 0.54, P = 0.003). COMT Met homozygotes had higher ASRS scores than Val homozygotes (P = 0.005). These findings are consistent with evidence of overlap between schizophrenia and ADHD and support an involvement of COMT genotype in ADHD features.
先前的研究表明，精神分裂症与注意力缺陷多动障碍（ADHD）之间可能存在重叠。研究评估了多巴胺相关基因中分裂型人格特质、ADHD特征与基因多态性之间的关系。31名健康的白人男性完成了拉斯特分裂型认知量表（RISC）和ADHD自我报告量表（ASRS）。分析了儿茶酚-O-甲基转移酶（COMT）Val158Met、D3型多巴胺受体（DRD3）Ser9Gly、DRD4可变串联重复序列（VNTR）以及SLC6A3 VNTR多态性。RISC评分与ASRS评分相关（r = 0.54，P = 0.003）。COMT Met纯合子的ASRS评分高于Val纯合子（P = 0.005）。这些发现与精神分裂症和ADHD之间存在重叠的证据一致，并支持COMT基因型与ADHD特征有关。
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