Barcellona Doris, Contu Paolo, Marongiu Francesco
Dipartimento di Scienze Mediche Internistiche, University of Cagliari, Cagliari, Italy.
J Thromb Thrombolysis. 2006 Dec;22(3):185-90. doi: 10.1007/s11239-006-9027-2.
The educational aspect of oral anticoagulant treatment is considered a possible cause of variability in anticoagulation levels. The aim of this prospective study was to investigate whether the time spent in the therapeutic range (TSTR) by patients taking oral anticoagulants could be improved by two different, consecutive educational approaches on the crucial aspects of oral anticoagulant therapy.
Between May and June 2004, validated interviews were conducted with 240 patients (128 male and 112 female, mean age 50 +/- 12 years) enrolled in the study. Three months later, the patients were randomly allocated to three groups. A course that focused on the questions in the interview was followed by the first group (n = 80); a brochure containing the correct answers to questions was given to the second (n = 81); nothing was provided for the third (n = 79).
A significant difference was found in the TSTR between the quarters preceding and following the interview. Mean TSTR increase was 13%. Patients that were randomly selected to attend the educational course, read a brochure or do nothing showed similar TSTR percentages in the quarter following the interview. A good control of the anticoagulant therapy (TSTR >70%) was maintained, with no significant variation during the following three-quarters.
A two-step educational approach for patients on long-term oral anticoagulation does not improve TSTR percentages in the short term.
口服抗凝治疗的教育方面被认为是抗凝水平变异性的一个可能原因。这项前瞻性研究的目的是调查,通过针对口服抗凝治疗关键方面的两种不同的、连续的教育方法,服用口服抗凝剂的患者在治疗范围内的时间(TSTR)是否能够得到改善。
2004年5月至6月期间,对纳入该研究的240名患者(128名男性和112名女性,平均年龄50±12岁)进行了经验证的访谈。三个月后,患者被随机分为三组。第一组(n = 80)接受了一个聚焦于访谈中问题的课程;第二组(n = 81)收到了一本包含问题正确答案的手册;第三组(n = 79)未接受任何干预。
在访谈前后的季度之间,TSTR存在显著差异。TSTR平均增加了13%。在访谈后的那个季度,随机选择参加教育课程、阅读手册或不接受任何干预的患者,其TSTR百分比相似。抗凝治疗得到了良好控制(TSTR>70%),在接下来的三个季度中没有显著变化。
对于长期接受口服抗凝治疗的患者,两步教育方法在短期内并不能提高TSTR百分比。