Kruszyński M, Kupryszewski G, Misterek K, Gumułka S
Institute of Chemistry, University of Gdańsk, Poland.
Pol J Pharmacol Pharm. 1990 Sep-Oct;42(5):483-90.
A new hexapeptide analog of Substance P, containing a C-terminal thioamide group in the molecule [( Glp6, Mett11]SP6-11) was synthesized: Glp-Phe-Phe-Gly-Leu-Mett-NH2. Conversion to thioamide was accomplished from tert-butoxycarbonyl-L-methionine amide (Boc-Met-NH2) using Lawesson's Reagent. Its contracting activity on isolated guinea-pig ileum was considerably lower than that of [Glp6]SP6-11.
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