由水杨醛衍生的三齿氨基醇催化硼烷对酮的对映选择性还原反应。
Enantioselective reduction of ketones with borane catalyzed by tridentate amino alcohols derived from salicylaldehyde.
作者信息
Lee Dong-Sheng
机构信息
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan, Republic of China.
出版信息
Chirality. 2007 Feb;19(2):148-51. doi: 10.1002/chir.20344.
PMID:17117400
Abstract
In the presence of tridentate chiral ligand 4e, 99% e.e. value was obtained by asymmetric reduction of ethyl benzoylacetate with borane in toluene at 25 degrees C. Various ligands and reaction conditions were investigated to develop a reasonable mechanism that explains the experimental outcomes.
摘要
在三齿手性配体4e存在的情况下，于25℃在甲苯中用硼烷对苯甲酰乙酸乙酯进行不对称还原，获得了99%的对映体过量值。研究了各种配体和反应条件，以建立一个合理的机理解释实验结果。
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