环孢素和FK506促进肝再生机制的研究。
Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506.
作者信息
Francavilla A, Starzl T E, Barone M, Zeng Q H, Porter K A, Zeevi A, Markus P M, van den Brink M R, Todo S
机构信息
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pennsylvania 15213.
出版信息
Hepatology. 1991 Jul;14(1):140-3. doi: 10.1002/hep.1840140123.
Abstract
Evidence could not be found of immune modulation of liver regeneration. The powerful immunosuppressive drug FK 506, which augments the response after partial hepatectomy in normal rats, had the same effect in T cell-deficient nude rats. The cytotoxicity of natural killer cells in treated nude rats was not significantly changed by FK 506 therapy. However, the serum of FK 506-treated nude rats increased hepatocyte proliferation when added to third-party hepatocyte cultures, suggesting that FK 506 had induced a serum growth factor in the nude rats or had suppressed an inhibitory factor. A hypothesis was advanced that FK 506 (and cyclosporine) affects hepatic growth by nonimmunological pathways.
摘要
未发现肝脏再生存在免疫调节的证据。强效免疫抑制药物FK 506可增强正常大鼠部分肝切除术后的反应，在T细胞缺陷的裸鼠中也有相同作用。FK 506治疗未使接受治疗的裸鼠体内自然杀伤细胞的细胞毒性发生显著改变。然而，将FK 506治疗的裸鼠血清添加到第三方肝细胞培养物中时，可增加肝细胞增殖，这表明FK 506在裸鼠中诱导产生了一种血清生长因子或抑制了一种抑制因子。有人提出一种假说，即FK 506（和环孢素）通过非免疫途径影响肝脏生长。
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