Eryilmaz A, Dagli M, Karabulut H, Sivas Acar F, Erkol Inal E, Gocer C
Department of Otolaryngology, Ankara Numune Research and Training Hospital, Ankara, Turkey.
J Laryngol Otol. 2007 Sep;121(9):845-9. doi: 10.1017/S0022215106004488. Epub 2006 Nov 24.
The aim of this study was to investigate hearing loss in patients with ankylosing spondylitis.
Prospective, case-control study.
Fifty-nine ankylosing spondylitis patients (118 ears) and 52 healthy control subjects (104 ears) were included. Pure tone audiometry at 250, 500, 1000, 2000, 4000 and 6000 Hz and immittance measures, including tympanometry and acoustic reflex tests, were performed in the patients and controls.
Sensorineural hearing loss was found in 21 patients (35.5 per cent), bilateral in 15 patients and unilateral in six. Pure tone thresholds significantly differed between patients and controls at all frequencies (p<0.05). There was no statistically significant difference between the right and the left ears' thresholds at all frequencies, except at 4000 Hz in ankylosing spondylitis patients. The right ears' thresholds were higher than those of the left ears. Patients' pure tone average (PTA) thresholds were significantly different from those of controls in all three PTA groups (i.e. 250 Hz; 500, 1000 and 2000 Hz; and 4000 and 6000 Hz) (p<0.05). The differences were most prominent in the higher frequencies.
Our findings suggest a decreased hearing level in ankylosing spondylitis patients, mostly at high frequencies, although the pure tone thresholds of patients and controls significantly differed at all frequencies.
本研究旨在调查强直性脊柱炎患者的听力损失情况。
前瞻性病例对照研究。
纳入59例强直性脊柱炎患者（118耳）和52例健康对照者（104耳）。对患者和对照者进行250、500、1000、2000、4000和6000Hz的纯音听力测定以及包括鼓室图和声反射测试在内的声导抗测量。
21例患者（35.5%）存在感音神经性听力损失，其中15例为双侧，6例为单侧。患者和对照者在所有频率下的纯音阈值均有显著差异（p<0.05）。除强直性脊柱炎患者在4000Hz时，所有频率下左右耳阈值无统计学显著差异。右耳阈值高于左耳。在所有三个纯音平均（PTA）组（即250Hz；500、1000和2000Hz；以及4000和6000Hz）中，患者的PTA阈值与对照者有显著差异（p<0.05）。差异在高频时最为显著。
我们的研究结果表明，强直性脊柱炎患者的听力水平下降，主要在高频，尽管患者和对照者在所有频率下的纯音阈值均有显著差异。
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