Murad Başar M, Tuğlu Devrim, Yilmaz Erdal, Başar Halil, Batislam Ertan
Department of Urology, Faculty of Medicine, University of Kirikkale, Kirikkale, Turkey.
Scand J Urol Nephrol. 2006;40(6):506-10. doi: 10.1080/00365590600589765.
To evaluate the correlation between International Index of Erectile Function (IIEF) questionnaire scores, nocturnal penile tumescence parameters and sildenafil response in patients with erectile dysfunction using a minimal investigations approach.
A total of 97 patients without any risk factors for erectile dysfunction were included. After completing the IIEF questionnaire, nocturnal penile tumescence monitoring was performed in all patients for 1 or 2 nights. Subsequently, sildenafil was given at a dosage of 50 or 100 mg according to the response. The relationship between nocturnal penile tumescence results, the severity of erectile dysfunction according to the IIEF questionnaire and sildenafil response was evaluated using Pearson's chi2 test.
Based on the questionnaire scores, 25 patients (25.8%) had mild, 44 (45.4%) had moderate and 28 (28.8%) had severe erectile dysfunction. Forty-four patients (45.4%) had normal and 53 (54.6%) had abnormal parameters after nocturnal penile tumescence recording. The sildenafil response was positive in 63 patients (64.9%) who were given 50 mg and in 26 (26.8%) who were given 100 mg. However, eight patients (8.2%) did not respond to sildenafil. While the severity of erectile dysfunction according to IIEF scores and the sildenafil response did not show any correlations with nocturnal penile tumescence results, there was a statistically significant relationship between sildenafil response and the severity of erectile dysfunction.
Changing concepts in the evaluation of ED have resulted in the use of effective therapeutic applications consistent with the degree of symptoms of patients without the waste of time caused by performing expensive, invasive, ineffective and time-consuming diagnostic tests.
采用最小化检查方法评估勃起功能障碍患者国际勃起功能指数（IIEF）问卷评分、夜间阴茎勃起参数与西地那非反应之间的相关性。
共纳入97例无勃起功能障碍任何危险因素的患者。完成IIEF问卷后，所有患者均进行1或2晚的夜间阴茎勃起监测。随后，根据反应给予50或100mg剂量的西地那非。采用Pearson卡方检验评估夜间阴茎勃起结果、根据IIEF问卷得出的勃起功能障碍严重程度与西地那非反应之间的关系。
根据问卷评分，25例患者（25.8%）患有轻度勃起功能障碍，44例（45.4%）患有中度勃起功能障碍，28例（28.8%）患有重度勃起功能障碍。夜间阴茎勃起记录后，44例患者（45.4%）参数正常，53例（54.6%）参数异常。给予50mg西地那非的63例患者（64.9%）和给予100mg西地那非的26例患者（26.8%）西地那非反应为阳性。然而，8例患者（8.2%）对西地那非无反应。虽然根据IIEF评分得出的勃起功能障碍严重程度和西地那非反应与夜间阴茎勃起结果未显示出任何相关性，但西地那非反应与勃起功能障碍严重程度之间存在统计学显著关系。
勃起功能障碍评估观念的转变使得能够使用与患者症状程度相符的有效治疗方法，而无需因进行昂贵、有创、无效且耗时的诊断检查而浪费时间。
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