尼帕病毒F和G蛋白基因DNA免疫的效果

Efficacy of DNA immunization with F and G protein genes of Nipah virus.

作者信息

Wang Xijun, Ge Jinying, Hu Sen, Wang Qinghua, Wen Zhiyun, Chen Hualan, Bu Zhigao

机构信息

National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, Harbin 150001, P.R. China.

出版信息

Ann N Y Acad Sci. 2006 Oct;1081:243-5. doi: 10.1196/annals.1373.029.

DOI:10.1196/annals.1373.029

PMID:17135518

Abstract

We investigated the antibody response of DNA immunization with two mammalian codon optimized envelope glycoprotein genes, F and G, of Nipah virus in a mouse model. The results indicated that G gene immunization elicited more significant specific serum IgG response and neutralization antibody response than F gene did, suggesting that the G gene DNA immunization is a potential vaccine strategy against Nipah virus.

摘要

我们在小鼠模型中研究了用尼帕病毒的两个哺乳动物密码子优化包膜糖蛋白基因F和G进行DNA免疫的抗体反应。结果表明，与F基因相比，G基因免疫引发了更显著的特异性血清IgG反应和中和抗体反应，这表明G基因DNA免疫是一种针对尼帕病毒的潜在疫苗策略。