人类免疫缺陷病毒相关的卡波西肉瘤：致病机制

HIV-associated Kaposi sarcoma: pathogenic mechanisms.

作者信息

Feller Liviu, Wood Neil H, Lemmer Johan

机构信息

Department of Periodontology and Oral Medicine, University of Limpopo, Medunsa, South Africa

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Oct;104(4):521-9. doi: 10.1016/j.tripleo.2006.08.015.

DOI:10.1016/j.tripleo.2006.08.015

PMID:17142074

Abstract

Kaposi sarcoma (KS) is a multicentric angioproliferative disorder characterized by spindle cell proliferation, neo-angiogenesis, inflammation, and edema. Human herpesvirus (HHV)-8, a gamma-herpesvirus, is a critical factor, but is not alone sufficient for the initiation of KS. Other cofactors such as human immunodeficiency virus (HIV), host-derived cytokines, chemokines, and growth factors are required for the development of KS. Whether HIV-associated KS is a reactive hyperplastic inflammatory lesion or a true neoplasm is still controversial. It is likely that HIV-associated KS begins as a reactive disorder that in some cases progresses to a monoclonal, an oligoclonal, and a polyclonal neoplasm.

摘要

卡波西肉瘤（KS）是一种多中心性血管增殖性疾病，其特征为梭形细胞增殖、新生血管形成、炎症和水肿。人疱疹病毒（HHV）-8，一种γ疱疹病毒，是一个关键因素，但并非引发KS的唯一充分条件。KS的发展还需要其他辅助因素，如人类免疫缺陷病毒（HIV）、宿主来源的细胞因子、趋化因子和生长因子。HIV相关的KS是一种反应性增生性炎症病变还是一种真正的肿瘤仍存在争议。HIV相关的KS很可能始于一种反应性疾病，在某些情况下会发展为单克隆、寡克隆和多克隆肿瘤。