Derrien Thomas, André Catherine, Galibert Francis, Hitte Christophe
CNRS UMR6061 Génétique et Développement, Université de Rennes1, IFR140, 2 Av du Pr. Léon Bernard, CS 34317, 35043, France.
Bioinformatics. 2007 Feb 15;23(4):498-9. doi: 10.1093/bioinformatics/btl618. Epub 2006 Dec 4.
AutoGRAPH is an interactive web server for automatic multi-species comparative genomics analyses based on personal datasets or pre-inserted public datasets. This program automatically identifies conserved segments (CS) and breakpoint regions, assesses the conservation of marker/gene order between organisms, constructs synteny maps for two to three species and generates high-quality, interactive displays facilitating the identification of chromosomal rearrangements. AutoGRAPH can also be used for the integration and comparison of several types of genomic resources (meiotic maps, radiation hybrid maps and genome sequences) for a single species, making AutoGRAPH a versatile tool for comparative genomics analysis.
http://genoweb.univ-rennes1.fr/tom_dog/AutoGRAPH/.
A description of the algorithm and additional information are available at http://genoweb.univ-rennes1.fr/tom_dog/AutoGRAPH/Tutorial.php.
AutoGRAPH是一个交互式网络服务器,用于基于个人数据集或预先插入的公共数据集进行自动多物种比较基因组学分析。该程序能自动识别保守区段(CS)和断点区域,评估生物体之间标记/基因顺序的保守性,构建两到三个物种的共线性图谱,并生成高质量的交互式显示,便于识别染色体重排。AutoGRAPH还可用于对单个物种的几种类型的基因组资源(减数分裂图谱、辐射杂种图谱和基因组序列)进行整合和比较,使AutoGRAPH成为比较基因组学分析的通用工具。
http://genoweb.univ-rennes1.fr/tom_dog/AutoGRAPH/。
算法描述和其他信息可在http://genoweb.univ-rennes1.fr/tom_dog/AutoGRAPH/Tutorial.php获取。