中国青海省东乡族和撒拉族15个短串联重复序列（STR）基因座的遗传多态性
Genetic polymorphisms of 15 STR loci of Chinese Dongxiang and Salar ethnic minority living in Qinghai Province of China.
作者信息
Deng Yajun, Zhu Bofeng, Yu Xiaoguang, Li Yuanzhe, Fang Junbang, Xiong Xin, Mu Haofang, Huang Yanqing, Shi Xiaotie
机构信息
Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, PR China.
出版信息
Leg Med (Tokyo). 2007 Jan;9(1):38-42. doi: 10.1016/j.legalmed.2006.08.003. Epub 2006 Dec 5.
Fifteen autosomal STRs loci were analyzed from two samples of 178 healthy unrelated autochthonous individuals of Chinese Dongxiang and Salar ethnic minority groups using a multiplex PCR system. Allele frequencies distribution and statistical parameters for all STR loci, D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA, were determined by the AmpFISTR Identifiler Kit. The observed genotype frequencies and expected of genotype frequencies were evaluated by chi(2)-test and the Fisher exact tests. chi(2)-test showed that the agreement with Hardy-Weinberg equilibrium (p>0.05) was for all studied STR loci of two populations. The data in the present study can be used greatly for routine forensic application in the region, and enrich Chinese ethnical genetic informational resources.
使用多重PCR系统对中国东乡族和撒拉族178名健康无血缘关系的本地个体的两个样本中的15个常染色体STR基因座进行了分析。通过AmpFISTR Identifiler试剂盒确定了所有STR基因座（D8S1179、D21S11、D7S820、CSF1PO、D3S1358、TH01、D13S317、D16S539、D2S1338、D19S433、vWA、TPOX、D18S51、D5S818和FGA）的等位基因频率分布和统计参数。通过卡方检验和Fisher精确检验评估观察到的基因型频率和预期的基因型频率。卡方检验表明，两个群体所有研究的STR基因座均符合哈迪-温伯格平衡（p>0.05）。本研究中的数据可极大地用于该地区的常规法医应用，并丰富中国民族遗传信息资源。
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