通过π-π堆积相互作用实现平行G-四链体DNA二聚化的动力学和热力学
Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA through pi-pi stacking interaction.
作者信息
Kato Yoshitake, Ohyama Takako, Nagatomo Shigenori, Mita Hajime, Yamamoto Yasuhiko
机构信息
Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2005(49):247-8. doi: 10.1093/nass/49.1.247.
PMID:17150726
Abstract
DNA fragments of d(TTAG(n)) (n = 3-5) form all-parallel G-quadruplexed structure in the presence of K+. We found that G-quadruplexed d(TTAG(n)) forms dimer through end-to-end stacking of the 3'-terminal G-tetrads. In this study, we report the structure of the dimer, and the dynamics and thermodynamics of the dimerization.
摘要
在钾离子存在的情况下，d(TTAG(n))（n = 3 - 5）的DNA片段形成全平行的G-四链体结构。我们发现，G-四链体d(TTAG(n))通过3'-末端G-四联体的端对端堆积形成二聚体。在本研究中，我们报告了二聚体的结构以及二聚化的动力学和热力学。
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