溃疡性结肠炎中的血清促炎细胞因子和黏附分子。

Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis.

作者信息

Umehara Yasushi, Kudo Masatoshi, Nakaoka Ryosuke, Kawasaki Toshihiko, Shiomi Mikio

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine Kinki University School of Medicine, Osaka-Sayama, Japan.

出版信息

Hepatogastroenterology. 2006 Nov-Dec;53(72):879-82.

PMID:17153445

Abstract

BACKGROUND/AIMS: The aim of this study was to define the correlation between serum markers, such as proinflammatory cytokines and adhesion molecules, and disease activity in ulcerative colitis (UC).

METHODOLOGY

Nineteen patients with UC treated in our hospital from April 2003 to June 2004, were enrolled into this study. We measured serum interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule (VCAM-1) from a blood sample. We investigated the correlation between these cytokine molecules and clinical activity.

RESULTS

Serum levels of IL-6 after treatment were significantly decreased proportionately as disease activity improved. Serum levels of IL-8 also significantly correlated with disease activity. On the other hand, serum levels of TNF-alpha were within the normal range in most of cases despite being in the active phase. There were also no significant differences between before and after treatment in serum levels of ICAM-1 or VCAM-1.

CONCLUSIONS

Serum IL-6 and IL-8 significantly reflected disease activity in patients with UC.

摘要

背景/目的：本研究旨在明确促炎细胞因子和黏附分子等血清标志物与溃疡性结肠炎（UC）疾病活动度之间的相关性。

方法

选取2003年4月至2004年6月在我院接受治疗的19例UC患者纳入本研究。我们从血样中检测血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子（VCAM-1）。我们研究了这些细胞因子分子与临床活动度之间的相关性。