具有增强抗菌活性的氟化吡啶鎓嵌段共聚物表面。

Surfaces of fluorinated pyridinium block copolymers with enhanced antibacterial activity.

作者信息

Krishnan Sitaraman, Ward Rebekah J, Hexemer Alexander, Sohn Karen E, Lee Kristen L, Angert Esther R, Fischer Daniel A, Kramer Edward J, Ober Christopher K

机构信息

Department of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.

出版信息

Langmuir. 2006 Dec 19;22(26):11255-66. doi: 10.1021/la061384v.

DOI:10.1021/la061384v

PMID:17154613

Abstract

Polystyrene-b-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure spectroscopy and X-ray photoelectron spectroscopy. The fluorinated pyridinium surfaces showed enhanced antibacterial activity compared to their nonfluorinated counterparts. Even a polymer with a relatively low molecular weight pyridinium block showed high antimicrobial activity. The bactericidal effect was found to be related to the molecular composition and organization in the top 2-3 nm of the surface and increased with increasing hydrophilicity and pyridinium concentration of the surface.

摘要

聚苯乙烯-b-聚（4-乙烯基吡啶）共聚物用1-溴己烷和6-全氟辛基-1-溴己烷进行季铵化。由这些聚合物制备的表面通过接触角测量、近边X射线吸收精细结构光谱和X射线光电子能谱进行表征。与未氟化的对应物相比，氟化吡啶鎓表面显示出增强的抗菌活性。即使是具有相对低分子量吡啶鎓嵌段的聚合物也显示出高抗菌活性。发现杀菌效果与表面顶部2-3nm的分子组成和排列有关，并且随着表面亲水性和吡啶鎓浓度的增加而增加。