[谷胱甘肽S-转移酶T1和M1基因缺失型对头颈癌发生影响的评估]
[Evaluation of the influence of GSTT1 and GSTM1 null genotypes in head and neck carcinogenesis].
作者信息
Goloni-Bertollo Eny Maria, Biselli Joice Matos, Corrêa Léa Carolina Delima, Maníglia José Victor, Rossit Andréa Regina Baptista, Ruiz Mariângela Torreglosa, Pavarino-Bertelli Erika Cristina
机构信息
Faculdade de Medicina de São José do Rio Preto--FAMERP e no departamento de Biologia da Unidade de Pesquisa em Genética e Biologia Molecular, UPGEM São José do Rio Preto, SP.
出版信息
Rev Assoc Med Bras (1992). 2006 Sep-Oct;52(5):365-8. doi: 10.1590/s0104-42302006000500028.
BACKGROUND
To evaluate the influence of GSTM1 and GSTT1 null genotypes in head and neck carcinogenesis.
METHODS
The frequencies of GSTM1 and GSTT1 null genotypes were evaluated by multiplex polymerase chain reaction (PCR) in 45 patients with head and neck squamous cell carcinoma and in 45 control group individuals. Both groups were composed of smokers paired by gender, age and race.
RESULTS
The GSTT1 null genotype was found in 24.4% of the patients and 17.7% of the control group (P= 0.606), while 44.4% of the patients and 48.8% of the control group were bearers of the GSTM1 null genotype (P=0.832). No associations between GSTT1 and GSTMI null genotypes and primary tumor sites were found.
CONCLUSION
In our study, it was impossible to establish the influence of the GSTT1 and GSTM1 null genotypes in head and neck carcinogenesis.
背景
评估谷胱甘肽 S-转移酶 M1（GSTM1）和谷胱甘肽 S-转移酶 T1（GSTT1）缺失基因型在头颈部癌变中的影响。
方法
采用多重聚合酶链反应（PCR）评估45例头颈部鳞状细胞癌患者和45例对照组个体中GSTM1和GSTT1缺失基因型的频率。两组均由按性别、年龄和种族配对的吸烟者组成。
结果
24.4%的患者和17.7%的对照组个体存在GSTT1缺失基因型（P = 0.606），而44.4%的患者和48.8%的对照组个体携带GSTM1缺失基因型（P = 0.832）。未发现GSTT1和GSTMI缺失基因型与原发肿瘤部位之间存在关联。
结论
在我们的研究中，无法确定GSTT1和GSTM1缺失基因型在头颈部癌变中的影响。
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