吸入性类固醇疗法对哮喘儿童呼出气一氧化氮及支气管反应性的影响。

Effect of inhaled steroid therapy on exhaled nitric oxide and bronchial responsiveness in children with asthma.

作者信息

Nishio Ken, Odajima Hiroshi, Motomura Chikako, Nakao Fumiya, Nishima Sankei

机构信息

Department of Pediatrics, School of Medicine, Fukuoka University, and Fukuoka National Hospital, 4-39-1 Yakatabaru, Minami-ku, Fukuoka 811-1394, Japan.

出版信息

J Asthma. 2006 Dec;43(10):739-43. doi: 10.1080/02770900601031524.

DOI:10.1080/02770900601031524

PMID:17169825

Abstract

Inhaled steroid therapy is reported to reduce the level of exhaled nitric oxide (eNO), but the effects of inhaled corticosteroids (ICS) on bronchial hyperresponsiveness (BHR) have been controversial. The aim of this study was to determine the effects of ICS on the relationship between eNO and BHR. Twenty-six children with asthma were recruited, including 14 children who were receiving ICS (ICS group) and 12 who were not (ICS-naive group). The fractional exhaled nitric oxide concentration (FE(NO)) was examined by the recommended online method. To evaluate BHR, an acetylcholine challenge test was performed. In the ICS-naive group, FE(NO) was significantly correlated with PC20 (p < 0.05, r = -0.70), but not in the ICS group. In conclusion, FE(NO) was significantly correlated with BHR in the ICS-naive group, but this relationship was not present in the ICS group. Our results suggest that the use of ICS should be taken into consideration when evaluating the relation between BHR and airway inflammation.

摘要

据报道，吸入性类固醇疗法可降低呼出一氧化氮（eNO）水平，但吸入性糖皮质激素（ICS）对支气管高反应性（BHR）的影响一直存在争议。本研究的目的是确定ICS对eNO与BHR之间关系的影响。招募了26名哮喘儿童，其中14名正在接受ICS治疗（ICS组），12名未接受ICS治疗（未使用ICS组）。采用推荐的在线方法检测呼出一氧化氮分数浓度（FE(NO)）。为评估BHR，进行了乙酰胆碱激发试验。在未使用ICS组中，FE(NO)与PC20显著相关（p < 0.05，r = -0.70），但在ICS组中并非如此。总之，在未使用ICS组中，FE(NO)与BHR显著相关，但在ICS组中不存在这种关系。我们的结果表明，在评估BHR与气道炎症之间的关系时应考虑ICS的使用情况。