Tyrer Peter, Baldwin David
Department of Psychological Medicine, Division of Neuroscience & Mental Health, Imperial College, London W6 8RP, UK.
Lancet. 2006 Dec 16;368(9553):2156-66. doi: 10.1016/S0140-6736(06)69865-6.
Generalised anxiety disorder is a persistent and common disorder, in which the patient has unfocused worry and anxiety that is not connected to recent stressful events, although it can be aggravated by certain situations. This disorder is twice as common in women than it is in men. Generalised anxiety disorder is characterised by feelings of threat, restlessness, irritability, sleep disturbance, and tension, and symptoms such as palpitations, dry mouth, and sweating. These symptoms are recognised as part of the anxiety syndrome rather than independent complaints. The symptoms overlap greatly with those of other common mental disorders and we could regard the disorder as part of a spectrum of mood and related disorders rather than an independent disorder. Generalised anxiety disorder has a relapsing course, and intervention rarely results in complete resolution of symptoms, but in the short term and medium term, effective treatments include psychological therapies, such as cognitive behavioural therapy; self-help approaches based on cognitive behavioural therapy principles; and pharmacological treatments, mainly selective serotonin reuptake inhibitors.
广泛性焦虑障碍是一种持续且常见的疾病,患者存在无特定指向的担忧和焦虑,这些担忧和焦虑与近期的应激事件无关,尽管某些情况可能会使其加重。这种疾病在女性中的发病率是男性的两倍。广泛性焦虑障碍的特征包括威胁感、坐立不安、易怒、睡眠障碍和紧张,以及心悸、口干和出汗等症状。这些症状被认为是焦虑综合征的一部分,而非独立的主诉。这些症状与其他常见精神障碍的症状有很大重叠,我们可以将该疾病视为情绪及相关障碍谱系的一部分,而非一种独立的疾病。广泛性焦虑障碍呈复发病程,干预很少能使症状完全缓解,但在短期和中期,有效的治疗方法包括心理治疗,如认知行为疗法;基于认知行为疗法原则的自助方法;以及药物治疗,主要是选择性5-羟色胺再摄取抑制剂。