伴随氨基糖苷识别的质子化平衡的简单核磁共振分析：新霉素B与一个23聚体RNA适配体结合时质子化状态的显著变化。
A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.
作者信息
Freire Felix, Cuesta Igor, Corzana Francisco, Revuelta Julia, González Carlos, Hricovini Milos, Bastida Agatha, Jiménez-Barbero Jesús, Asensio Juan Luis
机构信息
Instituto de Química Orgánica General (CSIC), c/Juan de la Cierva 3, Madrid, Spain.
出版信息
Chem Commun (Camb). 2007 Jan 14(2):174-6. doi: 10.1039/b611597g. Epub 2006 Oct 23.
DOI:10.1039/b611597g
PMID:17180237
Abstract
A complete characterisation of the protonation equilibrium that accompanies the molecular recognition of neomycin-B by a specific RNA receptor has been achieved by employing simple NMR measurements.
摘要
通过简单的核磁共振测量，已实现了对特定RNA受体与新霉素B分子识别过程中伴随的质子化平衡的完整表征。
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