Sivalingam Sivaprakasam, Hashim Hashim, Schwaibold Hartwig
Bristol Urological Institute, Southmead Hospital, Westbury-on-Trym, Bristol, UK.
Drugs. 2006;66(18):2339-55. doi: 10.2165/00003495-200666180-00006.
Epidemiological studies have demonstrated an age-stratified increase in the incidence and prevalence of erectile dysfunction (ED). There is a greater degree of openness today when discussing sexual matters and more information on the treatment of ED is available to the public through the media. Quality-of-life issues are now a matter of great importance to the aging population. Men and their partners are no longer prepared to merely accept ED as a natural consequence of aging. The advent of a simple and effective oral therapy for ED has also indirectly fueled the increase in treatment-seeking behaviour among men. Despite great strides in research into ED, our knowledge and understanding of the pathophysiological mechanisms is still in its infancy. As a result, we are able to treat only the symptom of ED rather than prevent it. Common diseases found in the population, such as diabetes mellitus and coronary artery disease appear to be risk factors for the development of ED. Therefore, physicians need to identify any underlying co-existing organic diseases in their patients presenting with ED. Whenever possible, patients are encouraged to attend their consultation sessions with their partners because ED is a condition affecting 'the couple' and not just the man. Psychogenic aspects of ED should also be explored during the consultation. Efforts need to be made to uncover and address the presence of any psychological stressors, if necessary with the help of a psychosexual therapist. The first-line treatment of ED is oral phosphodiesterase-5 inhibitors. For those who do not respond to oral therapy, there is no defined 'step-ladder' escalation in alternative therapy. It is up to the physician to discuss the options with the patient or couple and reach a decision based on their preference.
流行病学研究表明,勃起功能障碍(ED)的发病率和患病率随年龄增长呈分层上升趋势。如今,在讨论性问题时人们的开放程度更高,通过媒体,公众也能获取更多关于ED治疗的信息。生活质量问题如今对老年人群体至关重要。男性及其伴侣不再愿意仅仅将ED视为衰老的自然结果。一种简单有效的ED口服疗法的出现也间接促使男性寻求治疗的行为有所增加。尽管在ED研究方面取得了巨大进展,但我们对其病理生理机制的认识和理解仍处于起步阶段。因此,我们目前只能治疗ED的症状,而无法预防它。人群中常见的疾病,如糖尿病和冠状动脉疾病,似乎是ED发生的危险因素。因此,医生需要在ED患者中识别任何潜在的并存器质性疾病。只要有可能,应鼓励患者与伴侣一同参加咨询会诊,因为ED是一种影响“夫妻双方”而非仅男性一方的疾病。在会诊过程中还应探讨ED的心理因素。如有必要,需借助性心理治疗师的帮助,努力发现并解决任何心理压力源。ED的一线治疗方法是口服磷酸二酯酶-5抑制剂。对于那些对口服治疗无反应的患者而言,替代疗法中并没有明确的“阶梯式”升级方案。应由医生与患者或夫妻双方讨论各种选择,并根据他们的偏好做出决定。