捕获聚酮化合物生物合成过程中的瞬时蛋白质-蛋白质相互作用。

Trapping transient protein-protein interactions in polyketide biosynthesis.

作者信息

Schnarr Nathan A, Khosla Chaitan

机构信息

Department of Chemistry, Stanford University, Stanford, California 94305, USA.

出版信息

ACS Chem Biol. 2006 Dec 20;1(11):679-80. doi: 10.1021/cb600451d.

DOI:10.1021/cb600451d

PMID:17184129

Abstract

Transient biomolecular interactions are essential for biological processes, but strategies for studying them have remained elusive. A paper in this issue shows how natural enzymatic activities can be exploited to examine protein-protein interactions in fatty acid synthase.

摘要

瞬时生物分子相互作用对生物过程至关重要，但研究它们的策略一直难以捉摸。本期的一篇论文展示了如何利用天然酶活性来检测脂肪酸合酶中的蛋白质-蛋白质相互作用。