成纤维细胞生长因子-10通过调节G1期细胞周期蛋白和细胞周期蛋白依赖性激酶来防止过氧化氢诱导的细胞周期停滞。
Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases.
作者信息
Upadhyay D, Chang W, Wei K, Gao M, Rosen G D
机构信息
Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Rm H3143, Stanford, CA 94305-5236, USA.
出版信息
FEBS Lett. 2007 Jan 23;581(2):248-52. doi: 10.1016/j.febslet.2006.12.020. Epub 2006 Dec 18.
Abstract
We studied the effects of fibroblast growth factor (FGF-10) on H2O2-induced alveolar epithelial cell (AEC) G1 arrest and the role of G1 cyclins. FGF-10 prevented H2O2-induced AEC G1 arrest. FGF-10 induced 2-4-fold increase in cyclin E, cyclin A and CDKs (2,4) alone and in AEC treated with H2O2. H2O2 downregulated cyclin D1; FGF-10 blocked these effects. FGF-10 prevented H2O2-induced upregulation of CDK inhibitor, p21. SiRNAp21 blocked H2O2-induced downregulation of cyclins, CDKs and AEC G1 arrest. Accordingly, we provide first evidence that FGF-10 regulates G1 cyclins and CDKs, and prevents H2O2-induced AEC G1 arrest.
摘要
我们研究了成纤维细胞生长因子（FGF - 10）对过氧化氢（H2O2）诱导的肺泡上皮细胞（AEC）G1期阻滞的影响以及G1期细胞周期蛋白的作用。FGF - 10可防止H2O2诱导的AEC G1期阻滞。FGF - 10单独作用以及在H2O2处理的AEC中，均可使细胞周期蛋白E、细胞周期蛋白A和周期蛋白依赖性激酶（CDK2、CDK4）增加2 - 4倍。H2O2可下调细胞周期蛋白D1；FGF - 10可阻断这些作用。FGF - 10可防止H2O2诱导的细胞周期蛋白依赖性激酶抑制剂p21上调。小干扰RNA（SiRNA）p21可阻断H2O2诱导的细胞周期蛋白、周期蛋白依赖性激酶下调以及AEC G1期阻滞。因此，我们首次证明FGF - 10可调节G1期细胞周期蛋白和周期蛋白依赖性激酶，并防止H2O2诱导的AEC G1期阻滞。
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1
Fibroblast growth factor-10 prevents asbestos-induced alveolar epithelial cell apoptosis by a mitogen-activated protein kinase-dependent mechanism.
Am J Respir Cell Mol Biol. 2005 Mar;32(3):232-8. doi: 10.1165/rcmb.2004-0242OC. Epub 2004 Dec 23.
2
Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair.
Am J Respir Cell Mol Biol. 2004 Jul;31(1):107-13. doi: 10.1165/rcmb.2003-0064OC. Epub 2004 Feb 19.
3
FGF-10 prevents mechanical stretch-induced alveolar epithelial cell DNA damage via MAPK activation.
Am J Physiol Lung Cell Mol Physiol. 2003 Feb;284(2):L350-9. doi: 10.1152/ajplung.00161.2002.
4
H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression.
J Biol Chem. 2002 Apr 19;277(16):13761-70. doi: 10.1074/jbc.M111123200. Epub 2002 Feb 4.
5
Role of cyclins in epithelial response to oxidants.
Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 2):S81-4. doi: 10.1164/ajrccm.164.supplement_2.2106069.
6
Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody.
Oncogene. 2001 Apr 5;20(15):1913-22. doi: 10.1038/sj.onc.1204277.
7
Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein.
Exp Cell Res. 2001 May 1;265(2):234-41. doi: 10.1006/excr.2001.5160.
8
Regulation of G1 phase progression by growth factors and the extracellular matrix.
Cell Mol Life Sci. 2001 Jan;58(1):80-93. doi: 10.1007/PL00000780.
9
Pathways governing G1/S transition and their response to DNA damage.
FEBS Lett. 2001 Feb 16;490(3):117-22. doi: 10.1016/s0014-5793(01)02114-7.
10
Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle.
Curr Opin Cell Biol. 2000 Dec;12(6):676-84. doi: 10.1016/s0955-0674(00)00151-4.
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