肾脏中的血管紧张素：理解高血压的关键？
Angiotensin in the kidney: a key to understanding hypertension?
作者信息
Steckelings Ulrike Muscha, Rettig Rainer, Unger Thomas
机构信息
Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.
出版信息
Cell Metab. 2007 Jan;5(1):7-8. doi: 10.1016/j.cmet.2006.12.007.
A crosstransplantation study between genetically matched angiotensin AT1 receptor knockout and wild-type mice revealed that renal AT1 receptors are required for the development of angiotensin II-induced hypertension (). However, in this experimental setting, hypertension-related left ventricular hypertrophy seemed to depend on blood pressure elevation rather than on the expression of AT1 receptors in the heart.
一项在基因匹配的血管紧张素AT1受体敲除小鼠和野生型小鼠之间进行的交叉移植研究表明，肾AT1受体是血管紧张素II诱导的高血压发展所必需的（）。然而，在这种实验环境下，高血压相关的左心室肥厚似乎取决于血压升高，而非心脏中AT1受体的表达。
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