在慢性呼吸道感染的小鼠模型中，泰利霉素可抑制活菌数量，但不影响淋巴细胞聚集。
Telithromycin inhibits the number of viable bacteria but not lymphocyte accumulation in a murine model of chronic respiratory infection.
作者信息
Yanagihara Katsunori, Kuroki Misuzu, Higuchi Norihide, Ohno Hideaki, Higashiyama Yasuhito, Miyazaki Yoshitsugu, Hirakata Yoichi, Mukae Hiroshi, Tomono Kazunori, Mizuta Yohei, Kadota Jun-Ichi, Tsukamoto Kazuhiro, Kohno Shigeru
机构信息
Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki, Japan.
出版信息
Chemotherapy. 2007;53(1):10-3. doi: 10.1159/000098244. Epub 2006 Dec 28.
The 14-membered macrolides, such as clarithromycin (CAM) and erythromycin (EM), are effective against diffuse panbronchiolitis. However, there have been no studies on the effects of telithromycin (TEL) on chronic respiratory infection in vivo. In this study, we determined the effect of TEL on an experimental murine model of chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation. TEL significantly reduced the number of viable bacteria but had no effect on the proliferation of lymphocytes. In contrast, CAM decreased the number of lymphocytes but had no effect on the number of viable bacteria in the lung. These results suggest that TEL and CAM have different effects on chronic respiratory infection caused by P. aeruginosa.
14元大环内酯类药物，如克拉霉素（CAM）和红霉素（EM），对弥漫性泛细支气管炎有效。然而，关于泰利霉素（TEL）对体内慢性呼吸道感染影响的研究尚未见报道。在本研究中，我们确定了TEL对由铜绿假单胞菌形成生物膜引起的慢性呼吸道感染实验小鼠模型的影响。TEL显著减少了活菌数量，但对淋巴细胞增殖没有影响。相比之下，CAM减少了淋巴细胞数量，但对肺内活菌数量没有影响。这些结果表明，TEL和CAM对铜绿假单胞菌引起的慢性呼吸道感染有不同的影响。
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