神经肽Y受体对骨重塑的调控

The control of bone remodeling by neuropeptide Y receptors.

作者信息

Allison S J, Baldock P A, Herzog H

机构信息

Bone and Mineral Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.

出版信息

Peptides. 2007 Feb;28(2):320-5. doi: 10.1016/j.peptides.2006.05.029. Epub 2006 Dec 29.

DOI:10.1016/j.peptides.2006.05.029

PMID:17197054

Abstract

An important role for the neuropeptide Y receptor system in the regulation of bone formation was recently revealed with a significant elevation in trabecular bone formation and bone volume following germline or hypothalamus-specific deletion of neuropeptide Y2 receptors in mice. Subsequent studies have now demonstrated that this central pathway is distinct from that of the other centrally regulated bone formation pathway mediated by leptin. This review discusses these recent findings and outlines how these new pathways could translate into potential novel targets for the treatment of bone disease.

摘要

最近的研究表明，神经肽Y受体系统在骨形成调节中发挥着重要作用。在小鼠中，通过种系或下丘脑特异性缺失神经肽Y2受体后，小梁骨形成和骨体积显著增加。随后的研究表明，这条中枢途径与由瘦素介导的另一条中枢调节骨形成途径不同。本文综述了这些最新发现，并概述了这些新途径如何转化为治疗骨疾病的潜在新靶点。