Goldstein R Z, Tomasi D, Rajaram S, Cottone L A, Zhang L, Maloney T, Telang F, Alia-Klein N, Volkow N D
Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000, USA.
Neuroscience. 2007 Feb 23;144(4):1153-9. doi: 10.1016/j.neuroscience.2006.11.024. Epub 2006 Dec 29.
Our goal in the current report was to design a new functional magnetic resonance imaging (fMRI) task to probe the role of the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) in processing of salient symptom-related cues during the simultaneous performance of an unrelated task in drug-addicted persons. We used a novel fMRI color-word drug Stroop task in 14 individuals with cocaine use disorders; subjects had to press for color of drug vs. matched neutral words. Although there were no accuracy or speed differences between the drug and neutral conditions in the current sample of subjects, drug words were more negatively valenced than the matched neutral words. Further, consistent with prior reports in individuals with other psychopathologies using different Stroop fMRI paradigms, our more classical color-word Stroop design revealed bilateral activations in the caudal-dorsal anterior cingulate cortex (cdACC) and hypoactivations in the rostro-ventral anterior cingulate cortex/medial orbitofrontal cortex (rACC/mOFC). A trend for larger rACC/mOFC hypoactivations to the drug than neutral words did not survive whole-brain corrections. Nevertheless, correlation analyses indicated that (1) the more the cdACC drug-related activation, the more negative the valence attributed to the drug words (r=-0.86, P<0.0001) but not neutral words; and (2) the more the rACC/mOFC hypoactivation to drug minus neutral words, the more the errors committed specifically to the drug minus neutral words (r=0.85, P<0.0001). Taken together, results suggest that this newly developed drug Stroop fMRI task may be a sensitive biobehavioral assay of the functions recruited for the regulation of responses to salient symptom-related stimuli in drug-addicted individuals.
在本报告中，我们的目标是设计一项新的功能磁共振成像（fMRI）任务，以探究前扣带回皮质（ACC）和眶额皮质（OFC）在吸毒者执行无关任务时处理突出症状相关线索的过程中所起的作用。我们对14名患有可卡因使用障碍的个体使用了一种新颖的fMRI颜色-词语药物Stroop任务；受试者必须按下按钮以区分药物相关词语和匹配的中性词语的颜色。尽管在当前受试者样本中，药物相关词语和中性词语条件下的准确性或速度没有差异，但药物相关词语的负性效价比匹配的中性词语更高。此外，与先前使用不同Stroop fMRI范式对患有其他精神病理学个体的报告一致，我们更经典的颜色-词语Stroop设计显示，尾侧-背侧前扣带回皮质（cdACC）出现双侧激活，而吻侧-腹侧前扣带回皮质/内侧眶额皮质（rACC/mOFC）出现激活不足。rACC/mOFC对药物相关词语的激活不足比中性词语更大这一趋势在全脑校正后未达到统计学意义。然而，相关性分析表明：（1）cdACC与药物相关的激活越多，赋予药物相关词语的负性效价越高（r = -0.86，P < 0.0001），但与中性词语无关；（2）rACC/mOFC对药物减去中性词语的激活不足越多，专门针对药物减去中性词语所犯的错误就越多（r = 0.85，P < 0.0001）。综上所述，结果表明，这项新开发的药物Stroop fMRI任务可能是一种敏感的生物行为测定方法，用于检测吸毒个体对突出症状相关刺激的反应调节所涉及的功能。
