Kouvaris John R, Gogou Penelope V, Papacharalampous Xenofon N, Kostara Helen J, Balafouta Myrsini J, Vlahos Lambros J
Departement of Radiation Oncology, Aretaieion Hospital, Medical School, University of Athens, Greece.
Onkologie. 2006 Dec;29(12):568-70. doi: 10.1159/000096708. Epub 2006 Dec 11.
Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive primary malignancy, brain metastases of this type of tumor are even rarer.
A 51-year-old male patient with a solitary cerebral metastasis, diagnosed ten months after left pneumonectomy for a CBPB, was treated by surgery and accelerated hypofractionated radiotherapy.
The patient died 15 months after partial removal of the brain metastasis. Literature review revealed only 4 cases of solitary brain metastases from this type of malignancy. The present case is the second one reported with a combined treatment of surgery and radiotherapy resulting in the longest survival.
The best treatment for CBPB is difficult to determine because of the small number of cases, however, the combination of surgery with radiotherapy seems to be effective. The effectiveness of chemotherapy has not been ascertained.
经典双相肺母细胞瘤（CBPB）是一种罕见且侵袭性强的原发性恶性肿瘤，这类肿瘤发生脑转移更为罕见。
一名51岁男性患者，因CBPB行左肺切除术后10个月被诊断为孤立性脑转移，接受了手术及加速分割放疗。
患者在脑转移瘤部分切除术后15个月死亡。文献回顾显示，仅4例该类型恶性肿瘤的孤立性脑转移病例。本病例是第二例报道的采用手术和放疗联合治疗且生存时间最长的病例。
由于病例数量较少，CBPB的最佳治疗方案难以确定，然而，手术与放疗联合似乎有效。化疗的有效性尚未得到证实。
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