10-(二苯基亚甲基)-4-氮杂三环[5.2.1.0(2,6)]癸-8-烯-3,5-二酮氨基衍生物作为潜在精神药物和/或抗HIV药物的合成
Synthesis of amino derivatives of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione as potential psychotropic and/or anti HIV agents.
作者信息
Kossakowski Jerzy, Wojciechowska Anna, Kozioł Anna E
机构信息
Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland.
出版信息
Acta Pol Pharm. 2006 Jul-Aug;63(4):261-4.
PMID:17203861
Abstract
A series of amino derivatives of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0(2.6)]dec-8-ene-3,5-dione, analogues of chlorpromazine and aminoperazine have been prepared. These compounds are expected to have antipsychotic and/or anti HIV activity. Molecular structure of III was confirmed by an X-ray structure analysis. The cytotoxicity and anti HIV activity of derivatives I-IV were determined.
摘要
制备了一系列10 -（二苯基亚甲基）- 4 -氮杂三环[5.2.1.0(2.6)]癸- 8 -烯- 3,5 -二酮的氨基衍生物，它们是氯丙嗪和氨哌嗪的类似物。预计这些化合物具有抗精神病和/或抗HIV活性。通过X射线结构分析确定了III的分子结构。测定了衍生物I - IV的细胞毒性和抗HIV活性。
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