突触小泡在自发状态下以及活动期间的循环属于同一个小泡池。

Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool.

作者信息

Groemer Teja W, Klingauf Jurgen

机构信息

Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Goettingen, Germany.

出版信息

Nat Neurosci. 2007 Feb;10(2):145-7. doi: 10.1038/nn1831. Epub 2007 Jan 14.

DOI:10.1038/nn1831

PMID:17220885

Abstract

Recently, it has been claimed that vesicles recycling spontaneously and during activity belong to different pools. Here we simultaneously measured, using spectrally separable styryl dyes, the release kinetics of vesicles recycled spontaneously or upon stimulation and the effects of the v-ATPase blocker folimycin on the frequency of miniature postsynaptic currents in rat hippocampal neurons. Our results provide evidence as to the identities of the vesicle pools recycling at rest and during stimulation.

摘要

最近，有人声称自发循环的囊泡和活动期间循环的囊泡属于不同的池。在这里，我们使用光谱可分离的苯乙烯基染料同时测量了自发循环或受刺激时囊泡的释放动力学，以及V-ATP酶阻滞剂佛波霉素对大鼠海马神经元微小突触后电流频率的影响。我们的结果为静息和刺激时循环的囊泡池的身份提供了证据。