毒理学的未来——脂质过氧化的未来：从生物标志物到病因学。
Future of toxicology--lipid peroxidation in the future: from biomarker to etiology.
作者信息
Uchida Koji
机构信息
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
出版信息
Chem Res Toxicol. 2007 Jan;20(1):3-5. doi: 10.1021/tx600304n.
On the basis of a large number of reports concerning the detection of lipid peroxidation products as biomarkers in human diseases, there is no doubt that their steady-state levels increase under pathophysiological states associated with oxidative stress. The key question is whether they play any causative roles. This may be a matter of primary concern, which represents an important direction to pursue in the future of toxicology. My latest approach from autoimmune response induced by lipid peroxidation products will be illustrated.
基于大量有关检测脂质过氧化产物作为人类疾病生物标志物的报告，毫无疑问，在与氧化应激相关的病理生理状态下，它们的稳态水平会升高。关键问题是它们是否发挥任何致病作用。这可能是首要关注的问题，代表了毒理学未来需要探索的一个重要方向。我将阐述脂质过氧化产物诱导的自身免疫反应的最新研究方法。
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