Casadesus Gemma, Smith Mark A, Basu Samar, Hua Jing, Capobianco Dae E, Siedlak Sandra L, Zhu Xiongwei, Perry George
Department of Neuroscience, Case Western Reserve University, Cleveland, Ohio, USA.
Mol Neurodegener. 2007 Jan 22;2:2. doi: 10.1186/1750-1326-2-2.
Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been directly associated with inflammation and the production of free radicals are the prostaglandin 13,14-dihydro 15-keto PGF2alpha and the isoprostane 8-iso-PGF2alpha.
To further delineate the role of inflammatory and oxidative parameters in Alzheimer disease, in this study we evaluated the amount and localization of 13,14-dihydro 15-keto PGF2alpha and 8-iso-PGF2alpha in hippocampal post mortem tissue samples from age-matched Alzheimer disease and control patients. Our results demonstrate increased levels of 13,14-dihydro 15-keto PGF2alpha and 8-iso-PGF2alpha in the hippocampal pyramidal neurons of Alzheimer disease patients when compared to control patients.
These data not only support the shared mechanistic involvement of free radical damage and inflammation in Alzheimer disease, but also indicate that multiple pathogenic "hits" are likely necessary for both the development and propagation of Alzheimer disease.
炎症和氧化应激均参与阿尔茨海默病的发病机制，且已表明二者相互关联。与炎症和自由基产生直接相关的一类分子是前列腺素13,14 - 二氢15 - 酮PGF2α和异前列腺素8 - 异PGF2α。
为进一步阐明炎症和氧化参数在阿尔茨海默病中的作用，在本研究中，我们评估了年龄匹配的阿尔茨海默病患者和对照患者海马体死后组织样本中13,14 - 二氢15 - 酮PGF2α和8 - 异PGF2α的含量及定位。我们的结果表明，与对照患者相比，阿尔茨海默病患者海马体锥体细胞中13,14 - 二氢15 - 酮PGF2α和8 - 异PGF2α的水平升高。
这些数据不仅支持自由基损伤和炎症在阿尔茨海默病中共同的机制性参与，还表明多个致病“打击”可能是阿尔茨海默病发生和发展所必需的。
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