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残疾发生率、康复及死亡率动态变化中的教育差异:医学研究委员会认知功能与衰老研究(MRC CFAS)的研究结果

Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS).

作者信息

Jagger Carol, Matthews Ruth, Melzer David, Matthews Fiona, Brayne Carol

机构信息

Leicester Nuffield Research Unit, Department of Health Sciences, University of Leicester, Leicester, UK.

出版信息

Int J Epidemiol. 2007 Apr;36(2):358-65. doi: 10.1093/ije/dyl307. Epub 2007 Jan 25.

Abstract

BACKGROUND

This study aims to establish the extent of educational differences in the disability transitions of incidence, recovery and mortality in people aged 65 years and over, whether these can be explained by differentials in disease burden and their relative contribution to educational differences in prevalence and disability-free life expectancy (DFLE).

METHODS

A stratified random sample of 13 004 participants in five areas in England and Wales were interviewed in 1991-94 and followed up at 2, 6 (one centre only) and 10 years. Two levels of disability were analysed: mobility difficulty and activities of daily living (ADL) disability. We fitted logistic regression models to model educational differences in disability prevalence, incidence, recovery and mortality transitions. DFLE was calculated to assess the combined effect of the dynamic transitions.

RESULTS

Those with < or =9 years education had higher ADL and mobility disability prevalence and higher incidence and lower recovery of mobility disability. Differences in disability incidence remained after adjustment for comorbidity. Women with the lowest education had shorter life expectancies (1.7 years less at the age of 65 years) than the most educated and had even shorter DFLE (1.9 years free of ADL disability and 2.8 years free of mobility difficulty at the age of 65 years).

CONCLUSIONS

Differentials in education continue to contribute to prevalence of disability at ages beyond 65 years in both men and women and independently of diseases. These appear to be driven predominantly by differentials in disability incidence that also compound to produce greater differentials in DFLE between education groups than in total years lived.

摘要

背景

本研究旨在确定65岁及以上人群在残疾发生率、恢复情况和死亡率转变方面的教育差异程度,这些差异是否可以通过疾病负担差异来解释,以及它们对患病率和无残疾预期寿命(DFLE)教育差异的相对贡献。

方法

1991 - 1994年对英格兰和威尔士五个地区的13004名参与者进行分层随机抽样访谈,并在2年、6年(仅一个中心)和10年进行随访。分析了两个残疾水平:行动困难和日常生活活动(ADL)残疾。我们拟合了逻辑回归模型,以模拟残疾患病率、发病率、恢复情况和死亡率转变方面的教育差异。计算DFLE以评估动态转变的综合影响。

结果

受教育年限≤9年的人群ADL和行动残疾患病率更高,行动残疾发病率更高且恢复率更低。在调整合并症后,残疾发病率的差异仍然存在。教育程度最低的女性预期寿命(65岁时少1.7年)比受教育程度最高的女性短,且DFLE更短(65岁时无ADL残疾少1.9年,无行动困难少2.8年)。

结论

教育差异在65岁以上的男性和女性中持续导致残疾患病率,且独立于疾病因素。这些差异似乎主要由残疾发病率差异驱动,这也加剧了教育组之间DFLE的差异,使其大于总生存年限的差异。

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