Castaldo Eric T, Pinson C Wright, Feurer Irene D, Wright J Kelly, Gorden D Lee, Kelly Beau S, Chari Ravi S
Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN 37232-4753, USA.
Liver Transpl. 2007 Feb;13(2):234-8. doi: 10.1002/lt.20986.
Biliary complications following orthotopic liver transplantation have been reported in 10% to 30% of patients. Most surgeons perform an end-to-end choledochocholedochostomy with interrupted sutures for biliary reconstruction. The goal of this study was to compare biliary complications between interrupted suture (IS) and continuous suture (CS) techniques during liver transplantation in which an end-to-end choledochocholedochostomy over an internal biliary stent was performed. A retrospective cohort study of 100 consecutive liver transplants occurring between December 2003 and July 2005 was conducted. An end-to-end choledochocholedochostomy over an internal biliary stent was performed during liver transplantation. Data were analyzed using Kaplan-Meier methods, t tests, and chi-square tests of proportions. IS and CS techniques were used in 59 and 41 patients, respectively, for biliary reconstruction during liver transplantation. Mean follow-up time for the CS group was 17 +/- 8 months and 15 +/- 7 months for the IS group (P = .21). The overall biliary complication rate was 15%. There was no difference in the proportion of leaks (CS = 7.3%, IS = 8.5%; P = .83) or strictures (CS = 9.8%, IS = 5.1%; P = .37) between groups. Kaplan-Meier event rates show no difference in leaks (P = .79), strictures (P = .41), graft survival (P = .52), and patient survival (P = .32) by anastomosis type. In conclusion, there was no difference in biliary complications, graft survival, or patient survival between the 2 groups. CS and IS techniques for biliary reconstruction during liver transplantation yield comparable outcomes.
原位肝移植术后胆道并发症的报告发生率为10%至30%。大多数外科医生在进行胆道重建时采用间断缝合的端端胆管吻合术。本研究的目的是比较在肝移植过程中,采用内置胆道支架的端端胆管吻合术时,间断缝合(IS)技术和连续缝合(CS)技术的胆道并发症情况。对2003年12月至2005年7月期间连续进行的100例肝移植进行回顾性队列研究。肝移植期间进行了内置胆道支架的端端胆管吻合术。使用Kaplan-Meier方法、t检验和比例的卡方检验对数据进行分析。肝移植期间,分别有59例和41例患者采用IS和CS技术进行胆道重建。CS组的平均随访时间为17±8个月,IS组为15±7个月(P = 0.21)。总体胆道并发症发生率为15%。两组之间的渗漏比例(CS = 7.3%,IS = 8.5%;P = 0.83)或狭窄比例(CS = 9.8%,IS = 5.1%;P = 0.37)无差异。Kaplan-Meier事件发生率显示,按吻合类型分组,渗漏(P = 0.79)、狭窄(P = 0.41)、移植物存活率(P = 0.52)和患者存活率(P = 0.32)均无差异。总之,两组之间在胆道并发症、移植物存活率或患者存活率方面无差异。肝移植期间用于胆道重建的CS和IS技术产生的结果相当。