Lundh Charlotta, Lindencrona Ulrika, Schmitt Anneli, Nilsson Mikael, Forssell-Aronsson Eva
Department of Radiation Physics, Göteborg University, Göteborg, Sweden.
Cancer Biother Radiopharm. 2006 Dec;21(6):591-600. doi: 10.1089/cbr.2006.21.591.
Free 211At has been proposed for therapy of anaplastic thyroid carcinoma (ATC). However, no extensive biodistribution study comparing tumor-bearing and nontumor-bearing mice has previously been performed. The aim of this study was to perform a complete evaluation of the biodistribution of 211At, both for normal and ATC-bearing mice. For comparison, the biodistribution of 125I- was simultaneously studied. Dosimetric evaluations were performed to investigate if (211)At can be used for therapy of ATC.
Athymic nude mice were subcutaneously injected with either of two human ATC cell lines, HTh83 and KAT-4. Tumor-bearing and nontumor-bearing mice were injected intravenously with 0.3 MBq 211At and 0.3 MBq 125I- simultaneously. The mice were sacrificed 4-24 hours after injection, and the activity concentrations in tissues were determined.
Except for the thyroid, the concentration of 211At was higher than that of 125I- in the tissues. The uptake of 211At was primarily high in NIS-expressing organs. Furthermore, the absorbed doses to these organs were higher than both tumor types.
The biodistribution of 211At and 125I- differed in this animal model. The higher mean absorbed dose from 211At in several organs than in tumor tissue restricts the possibility of using free 211At for therapy of ATC.
游离的砹-211已被提议用于治疗间变性甲状腺癌（ATC）。然而，此前尚未进行过比较荷瘤小鼠和非荷瘤小鼠的广泛生物分布研究。本研究的目的是对正常小鼠和荷ATC小鼠体内砹-211的生物分布进行全面评估。为作比较，同时研究了碘-125的生物分布。进行了剂量学评估，以研究砹-211是否可用于治疗ATC。
将两种人ATC细胞系HTh83和KAT-4中的一种皮下注射到无胸腺裸鼠体内。给荷瘤小鼠和非荷瘤小鼠同时静脉注射0.3 MBq的砹-211和0.3 MBq的碘-125。注射后4至24小时处死小鼠，并测定组织中的活度浓度。
除甲状腺外，组织中砹-211的浓度高于碘-125。砹-211的摄取主要在表达NIS的器官中较高。此外，这些器官的吸收剂量高于两种肿瘤类型。
在该动物模型中，砹-211和碘-125的生物分布不同。砹-211在几个器官中的平均吸收剂量高于肿瘤组织，这限制了使用游离砹-211治疗ATC的可能性。
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