感染阴道毛滴虫会增加感染HIV-1的风险。

Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition.

作者信息

McClelland R Scott, Sangare Laura, Hassan Wisal M, Lavreys Ludo, Mandaliya Kishorchandra, Kiarie James, Ndinya-Achola Jeckoniah, Jaoko Walter, Baeten Jared M

机构信息

Department of Medicine, University of Washington, Seattle, WA 98104, USA.

出版信息

J Infect Dis. 2007 Mar 1;195(5):698-702. doi: 10.1086/511278. Epub 2007 Jan 22.

DOI:10.1086/511278

PMID:17262712

Abstract

We conducted a prospective study among women in Mombasa, Kenya, to determine whether Trichomonas vaginalis infection was associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) infection. At monthly follow-up visits, laboratory screening for HIV-1 and genital tract infections was conducted. Among 1335 HIV-1-seronegative women monitored for a median of 566 days, there were 806 incident T. vaginalis infections (23.6/100 person-years), and 265 women seroconverted to HIV-1 (7.7/100 person-years). Trichomoniasis was associated with a 1.52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women.

摘要

我们在肯尼亚蒙巴萨的女性中开展了一项前瞻性研究，以确定阴道毛滴虫感染是否与1型人类免疫缺陷病毒（HIV-1）感染风险增加相关。在每月的随访中，对HIV-1和生殖道感染进行实验室筛查。在1335名HIV-1血清阴性的女性中，中位监测时间为566天，有806例阴道毛滴虫感染（23.6/100人年），265名女性HIV-1血清转化（7.7/100人年）。在对潜在混杂因素进行调整后，滴虫病与HIV-1感染风险增加1.52倍（95%置信区间为1.04-2.24倍）相关。阴道毛滴虫感染的治疗和预防可降低女性感染HIV-1的风险。