鼠尾草中鼠尾草酸对氨基糖苷类抗生素抗菌活性的增强作用。
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis.
作者信息
Horiuchi Kumiko, Shiota Sumiko, Kuroda Teruo, Hatano Tsutomu, Yoshida Takashi, Tsuchiya Tomofusa
机构信息
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
出版信息
Biol Pharm Bull. 2007 Feb;30(2):287-90. doi: 10.1248/bpb.30.287.
We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.
我们发现，鼠尾草（丹参）的粗提物降低了耐万古霉素肠球菌（VRE）中氨基糖苷类药物的最低抑菌浓度（MIC）。我们从提取物中分离出有效化合物，并将其鉴定为二萜类化合物之一的鼠尾草酸。鼠尾草酸显示出较弱的抗菌活性，并大大降低了VRE中各种氨基糖苷类药物的MIC（增强了氨基糖苷类药物的抗菌活性）以及其他一些类型抗菌剂的MIC。相关化合物迷迭香酸也显示出类似的活性。鼠尾草酸和迷迭香酸与庆大霉素的作用具有协同性。
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