急性冠状动脉综合征中循环的人类单核细胞表达一种特征性蛋白质组学图谱。

Circulating human monocytes in the acute coronary syndrome express a characteristic proteomic profile.

作者信息

Barderas María G, Tuñón José, Dardé Verónica M, De la Cuesta Fernando, Durán María C, Jiménez-Nácher José J, Tarín Nieves, López-Bescós Lorenzo, Egido Jesús, Vivanco Fernando

机构信息

Department of Immunology, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain.

出版信息

J Proteome Res. 2007 Feb;6(2):876-86. doi: 10.1021/pr0601990.

DOI:10.1021/pr0601990

PMID:17269745

Abstract

We examined the proteome of circulating monocytes of patients with acute coronary syndrome at different times in comparison to that of patients with stable coronary artery disease. On admission, the expression of 18 spot proteins was altered, 10 of which were totally absent. This pattern changed progressively, and at 6 months, there were no differences with the monocyte proteome of stable patients.

摘要

我们检测了急性冠状动脉综合征患者在不同时间点循环单核细胞的蛋白质组，并与稳定型冠状动脉疾病患者的进行比较。入院时，18种斑点蛋白的表达发生了改变，其中10种完全缺失。这种模式逐渐变化，到6个月时，与稳定型患者的单核细胞蛋白质组没有差异。