Sathya A, Prabhakar S, Sangha S P S, Ghuman S P S
Department of Animal Reproduction, Gynaecology and Obstetrics, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
Vet Res Commun. 2007 Oct;31(7):809-18. doi: 10.1007/s11259-007-0116-2.
The aim of the study was to evaluate oxidative stress around parturition in normally calved and dystocia-affected buffaloes and the clinical efficacy of vitamin E and selenium (Se) in reducing the effects in buffaloes suffering from dystocia. Plasma cortisol concentration, erythrocytic malondialdehyde (MDA) level and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were evaluated in dystocia-affected (supplemented (n = 8) and unsupplemented (n = 5) with vitamin E and Se) and normally calved (unsupplemented; n = 6) buffaloes. The decline in plasma cortisol concentration, MDA level and SOD activity was greater in the group of dystocia-affected buffaloes supplemented with vitamin E and Se (78.62 +/- 2.7%, 13.38 +/- 9.75% and 28.83 +/- 7.72%, respectively) than in the unsupplemented group (54.33 +/- 12.62%, 3.48 +/- 4.16% and 17.69 +/- 12.93%, respectively). These results suggests that supplementation with antioxidants like vitamin E and Se may be beneficial in reducing oxidative stress in dystocia-affected buffaloes in the immediate postpartum period.
本研究的目的是评估正常分娩和难产水牛分娩前后的氧化应激情况，以及维生素E和硒（Se）在减轻难产水牛氧化应激影响方面的临床疗效。对受难产影响的（补充（n = 8）和未补充（n = 5）维生素E和硒）以及正常分娩的（未补充；n = 6）水牛，评估其血浆皮质醇浓度、红细胞丙二醛（MDA）水平、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性。补充维生素E和硒的受难产影响的水牛组，其血浆皮质醇浓度、MDA水平和SOD活性的下降幅度（分别为78.62 +/- 2.7%、13.38 +/- 9.75%和28.83 +/- 7.72%）大于未补充组（分别为54.33 +/- 12.62%、3.48 +/- 4.16%和17.69 +/- 12.93%）。这些结果表明，补充维生素E和硒等抗氧化剂可能有助于减轻产后早期受难产影响的水牛的氧化应激。
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