Lloyd Brendan M, Luginbuhl Ryan D, Brenner Michael J, Rocque Brandon G, Tung Thomas H, Myckatyn Terence M, Hunter Daniel A, Mackinnon Susan E, Borschel Gregory H
Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
Microsurgery. 2007;27(2):138-45. doi: 10.1002/micr.20318.
We have recently shown in experimental nerve injury models that nerve regeneration is enhanced across a motor nerve graft as compared with a sensory nerve graft. To test the hypothesis that nerve architecture may mediate the beneficial effect of motor nerve grafting, we developed a model of disrupted nerve architecture in which motor and sensory nerve fragments were introduced into silicone conduits. Lewis rats were randomized to 5 experimental groups: nerve repair with motor nerve fragments, sensory nerve fragments, mixed nerve fragments, saline-filled conduit (negative control), or nerve isograft (positive control). At 6, 9, or 12 weeks, animals were sacrificed and nerve tissues were analyzed by quantitative histomorphometry. No significant differences were observed between the motor, sensory, and mixed nerve fragment groups. These findings suggest that intact nerve architecture, regardless of neurotrophic or biochemical factors, is a prerequisite for the beneficial effect of motor nerve grafting.
我们最近在实验性神经损伤模型中表明，与感觉神经移植物相比，运动神经移植物能增强神经再生。为了验证神经结构可能介导运动神经移植有益效果的假说，我们建立了一种神经结构破坏模型，即将运动和感觉神经片段植入硅胶导管。将Lewis大鼠随机分为5个实验组：用运动神经片段、感觉神经片段、混合神经片段进行神经修复，填充生理盐水的导管（阴性对照），或神经同种异体移植（阳性对照）。在6周、9周或12周时，处死动物并通过定量组织形态学分析神经组织。运动、感觉和混合神经片段组之间未观察到显著差异。这些发现表明，完整的神经结构，无论神经营养或生化因素如何，都是运动神经移植产生有益效果的先决条件。
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