劳氏肉瘤病毒激活鸡成纤维细胞中的胚胎珠蛋白基因。
Rous sarcoma virus activates embryonic globin genes in chicken fibroblasts.
作者信息
Groudine M, Weintraub H
出版信息
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4464-8. doi: 10.1073/pnas.72.11.4464.
Abstract
Complementary DNA (cDNA) specific for chick globin mRNA sequences fails to hybridize to total RNA extracted from chicken fibroblasts. After infection by Rous sarcoma virus, RNA complementary to globin cDNA is detectable in 100-500 copies per cell. Infection of fibroblasts with the transformation defective (td) deletion mutant of Rous sarcoma virus leads to normal virus production, but not to host cell transformation or accumulation of RNA sequences complementary to globin cDNA. Our evidence shows that the globin genes activated by Rous sarcoma virus are those specified by embryonic chick red cells; adult-specific globin sequences were not detected.
摘要
对鸡珠蛋白mRNA序列具有特异性的互补DNA（cDNA）无法与从鸡成纤维细胞中提取的总RNA杂交。经劳氏肉瘤病毒感染后，每个细胞中可检测到100 - 500个拷贝的与珠蛋白cDNA互补的RNA。用劳氏肉瘤病毒的转化缺陷（td）缺失突变体感染成纤维细胞，可导致正常的病毒产生，但不会导致宿主细胞转化或与珠蛋白cDNA互补的RNA序列积累。我们的证据表明，劳氏肉瘤病毒激活的珠蛋白基因是胚胎期鸡红细胞所特有的基因；未检测到成年期特异性珠蛋白序列。
相似文献
1
Rous sarcoma virus activates embryonic globin genes in chicken fibroblasts.劳氏肉瘤病毒激活鸡成纤维细胞中的胚胎珠蛋白基因。
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4464-8. doi: 10.1073/pnas.72.11.4464.
2
Activation of cellular genes by avian RNA tumor viruses.禽RNA肿瘤病毒对细胞基因的激活作用。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5351-4. doi: 10.1073/pnas.77.9.5351.
3
Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts.劳氏肉瘤病毒转化的鸡胚成纤维细胞中胶原蛋白信使核糖核酸水平降低。
J Biol Chem. 1978 Aug 25;253(16):5869-74.
4
Mechanism of transfection of chicken embryo fibroblasts by Rous sarcoma virus DNA.劳氏肉瘤病毒DNA转染鸡胚成纤维细胞的机制。
J Virol. 1978 Oct;28(1):45-52. doi: 10.1128/JVI.28.1.45-52.1978.
5
Integration of proviral DNA in chicken cells infected with Schmidt-Ruppin Rous sarcoma virus is not enhanced by DNA repair.感染施密特 - 鲁平氏劳斯肉瘤病毒的鸡细胞中前病毒DNA的整合不会因DNA修复而增强。
J Virol. 1977 Sep;23(3):533-42. doi: 10.1128/JVI.23.3.533-542.1977.
6
7
Nucleotide sequence relationships of avian RNA tumor viruses: measurement of the deletion in a transformation-defective mutant of Rous sarcoma virus.禽RNA肿瘤病毒的核苷酸序列关系：劳氏肉瘤病毒转化缺陷型突变体中缺失的测定。
J Virol. 1974 Apr;13(4):837-46. doi: 10.1128/JVI.13.4.837-846.1974.
8
Changes in acyl group composition of phospholipids from chicken embryonic fibroblasts after transformation by Rous sarcoma virus.
Biochem Biophys Res Commun. 1972 Oct 6;49(1):114-20. doi: 10.1016/0006-291x(72)90016-2.
9
10
Oncogene and its production of an avian sarcoma virus Y73.癌基因及其在禽肉瘤病毒Y73中的产生。
Princess Takamatsu Symp. 1982;12:275-83.
引用本文的文献
1
Hemoglobin expression in nonerythroid cells: novel or ubiquitous?非红细胞中的血红蛋白表达：是新奇的还是普遍存在的？
Int J Inflam. 2014;2014:803237. doi: 10.1155/2014/803237. Epub 2014 Nov 5.
2
Hemoglobin induction in mouse macrophages.小鼠巨噬细胞中的血红蛋白诱导
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6643-7. doi: 10.1073/pnas.96.12.6643.
3
Intergenic transcription and transinduction of the human beta-globin locus.人类β-珠蛋白基因座的基因间转录和反式诱导
Genes Dev. 1997 Oct 1;11(19):2494-509. doi: 10.1101/gad.11.19.2494.
4
Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts.一个在v-src转化的3Y1大鼠成纤维细胞中呈负调控的cDNA的分子克隆与特性分析
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2593-7. doi: 10.1073/pnas.90.7.2593.
5
6
Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.癌基因编码的蛋白酪氨酸激酶对纤溶酶原激活物基因表达的差异调节
Mol Cell Biol. 1993 Sep;13(9):5888-97. doi: 10.1128/mcb.13.9.5888-5897.1993.
7
Role of endogenous cat retrovirus in cell differentiation.内源性猫逆转录病毒在细胞分化中的作用。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7371-5. doi: 10.1073/pnas.79.23.7371.
8
Developmental shifts in frequency distribution of polysomal mRNA and their posttranscriptional regulation in the sea urchin embryo.海胆胚胎中多聚核糖体mRNA频率分布的发育变化及其转录后调控。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4653-6. doi: 10.1073/pnas.77.8.4653.
9
Vimentin gene expression during myogenesis: two functional transcripts from a single copy gene.波形蛋白基因在肌生成过程中的表达：来自单拷贝基因的两种功能性转录本。
Nucleic Acids Res. 1983 Dec 10;11(23):8317-32. doi: 10.1093/nar/11.23.8317.
10
The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells.大鼠生长激素基因在肝癌细胞中的表达水平比在垂体前叶细胞中的表达水平至少低八个数量级。
Mol Cell Biol. 1983 Aug;3(8):1460-7. doi: 10.1128/mcb.3.8.1460-1467.1983.
本文引用的文献
1
Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.DNA中的重复序列。数以十万计的DNA序列拷贝已被纳入高等生物的基因组中。
Science. 1968 Aug 9;161(3841):529-40. doi: 10.1126/science.161.3841.529.
2
Three abundance classes in HeLa cell messenger RNA.HeLa细胞信使核糖核酸中的三种丰度类别。
Nature. 1974 Jul 19;250(463):199-204. doi: 10.1038/250199a0.
3
Lineage-dependent transcription of globin genes.珠蛋白基因的谱系依赖性转录。
Cell. 1974 Nov;3(3):243-7. doi: 10.1016/0092-8674(74)90138-x.
4
Non-repetitive DNA transcription in mouse cells grown in tissue culture.在组织培养中生长的小鼠细胞中的非重复DNA转录
Nat New Biol. 1973 Jun 13;243(128):195-8. doi: 10.1038/newbio243195a0.
5
An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses.一种与致癌病毒转化成纤维细胞相关的酶功能。I. 禽RNA肿瘤病毒转化的鸡胚成纤维细胞培养物。
J Exp Med. 1973 Jan 1;137(1):85-111. doi: 10.1084/jem.137.1.85.
6
Antiinflammatory effects of murine malignant cells.小鼠恶性细胞的抗炎作用。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4052-6. doi: 10.1073/pnas.71.10.4052.
7
Sequence at the 3' end of globin mRNA shows homology with immunoglobulin light chain mRNA.珠蛋白信使核糖核酸3'末端的序列与免疫球蛋白轻链信使核糖核酸显示出同源性。
Nature. 1974 Nov 29;252(5482):359-62. doi: 10.1038/252359a0.
8
Alpha-fetoprotein as a marker of embryo-specific differentiations in normal and tumor tissues.甲胎蛋白作为正常组织和肿瘤组织中胚胎特异性分化的标志物。
Transplant Rev. 1974;20(0):3-37. doi: 10.1111/j.1600-065x.1974.tb00139.x.
9
Structural studies on chick embryonic hemoglobins.鸡胚胎血红蛋白的结构研究。
J Biol Chem. 1974 Jun 25;249(12):3960-72.
10
Studies on the control of differentiation of murine virus-induced erythroleukemic cells.小鼠病毒诱导的红白血病细胞分化控制的研究。
Curr Top Dev Biol. 1974;8:81-101. doi: 10.1016/s0070-2153(08)60606-7.
Zotero 插件