枯草芽孢杆菌YycI的晶体结构揭示了一类不同寻常的传感器组氨酸激酶调节蛋白中两个成员的共同折叠结构。
The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.
作者信息
Santelli Eugenio, Liddington Robert C, Mohan Michael A, Hoch James A, Szurmant Hendrik
机构信息
Division of Cellular Biology, Mail code MEM-116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
J Bacteriol. 2007 Apr;189(8):3290-5. doi: 10.1128/JB.01937-06. Epub 2007 Feb 16.
Abstract
YycI and YycH are two membrane-anchored periplasmic proteins that regulate the essential Bacillus subtilis YycG histidine kinase through direct interaction. Here we present the crystal structure of YycI at a 2.9-A resolution. YycI forms a dimer, and remarkably the structure resembles that of the two C-terminal domains of YycH despite nearly undetectable sequence homology (10%) between the two proteins.
摘要
YycI和YycH是两种膜锚定的周质蛋白，它们通过直接相互作用调节枯草芽孢杆菌必需的YycG组氨酸激酶。在此，我们展示了分辨率为2.9埃的YycI晶体结构。YycI形成二聚体，并且值得注意的是，尽管这两种蛋白质之间的序列同源性几乎检测不到（10%），但其结构类似于YycH的两个C端结构域的结构。
相似文献
1
The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.
J Bacteriol. 2007 Apr;189(8):3290-5. doi: 10.1128/JB.01937-06. Epub 2007 Feb 16.
2
YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol. 2007 Apr;189(8):3280-9. doi: 10.1128/JB.01936-06. Epub 2007 Feb 16.
3
An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins.
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5891-6. doi: 10.1073/pnas.0800247105. Epub 2008 Apr 11.
4
YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol. 2005 Aug;187(15):5419-26. doi: 10.1128/JB.187.15.5419-5426.2005.
5
Structure of the oxygen sensor in Bacillus subtilis: signal transduction of chemotaxis by control of symmetry.
Structure. 2003 Sep;11(9):1097-110. doi: 10.1016/s0969-2126(03)00169-2.
6
A role for the essential YycG sensor histidine kinase in sensing cell division.
Mol Microbiol. 2011 Jan;79(2):503-22. doi: 10.1111/j.1365-2958.2010.07464.x. Epub 2010 Nov 29.
7
The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.
Protein Sci. 2006 Apr;15(4):929-34. doi: 10.1110/ps.052064406.
8
Extracytoplasmic PAS-like domains are common in signal transduction proteins.
J Bacteriol. 2010 Feb;192(4):1156-9. doi: 10.1128/JB.01508-09. Epub 2009 Dec 11.
9
The essential YycFG two-component system of Bacillus subtilis.
Methods Enzymol. 2007;422:396-417. doi: 10.1016/S0076-6879(06)22020-2.
10
Structural Studies on the Extracellular Domain of Sensor Histidine Kinase YycG from Staphylococcus aureus and Its Functional Implications.
J Mol Biol. 2016 Jul 31;428(15):3074-89. doi: 10.1016/j.jmb.2016.06.019. Epub 2016 Jul 4.
引用本文的文献
1
The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity.
Elife. 2025 Sep 9;14:RP108061. doi: 10.7554/eLife.108061.
2
Monoclonal Antibodies Specific to the Extracellular Domain of Histidine Kinase YycG of Inhibit Biofilm Formation.
Front Microbiol. 2020 Aug 7;11:1839. doi: 10.3389/fmicb.2020.01839. eCollection 2020.
3
YycH and YycI Regulate Expression of Autolysins by Activation of WalRK Phosphorylation.
Microorganisms. 2020 Jun 9;8(6):870. doi: 10.3390/microorganisms8060870.
4
Highly Sensitive, Breathable, and Flexible Pressure Sensor Based on Electrospun Membrane with Assistance of AgNW/TPU as Composite Dielectric Layer.
Sensors (Basel). 2020 Apr 26;20(9):2459. doi: 10.3390/s20092459.
5
Identification of Genes Controlled by the Essential YycFG Two-Component System Reveals a Role for Biofilm Modulation in .
Front Microbiol. 2017 Apr 26;8:724. doi: 10.3389/fmicb.2017.00724. eCollection 2017.
6
Transcriptional Analysis and Subcellular Protein Localization Reveal Specific Features of the Essential WalKR System in Staphylococcus aureus.
PLoS One. 2016 Mar 21;11(3):e0151449. doi: 10.1371/journal.pone.0151449. eCollection 2016.
7
Inactivation of the Autolysis-Related Genes lrgB and yycI in Staphylococcus aureus Increases Cell Lysis-Dependent eDNA Release and Enhances Biofilm Development In Vitro and In Vivo.
PLoS One. 2015 Sep 25;10(9):e0138924. doi: 10.1371/journal.pone.0138924. eCollection 2015.
8
ATP forms a stable complex with the essential histidine kinase WalK (YycG) domain.
Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):839-45. doi: 10.1107/S090744491201373X. Epub 2012 Jun 15.
9
Purification and activity testing of the full-length YycFGHI proteins of Staphylococcus aureus.
PLoS One. 2012;7(1):e30403. doi: 10.1371/journal.pone.0030403. Epub 2012 Jan 20.
10
A role for the essential YycG sensor histidine kinase in sensing cell division.
Mol Microbiol. 2011 Jan;79(2):503-22. doi: 10.1111/j.1365-2958.2010.07464.x. Epub 2010 Nov 29.
本文引用的文献
1
Processing of X-ray diffraction data collected in oscillation mode.
Methods Enzymol. 1997;276:307-26. doi: 10.1016/S0076-6879(97)76066-X.
2
YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol. 2007 Apr;189(8):3280-9. doi: 10.1128/JB.01936-06. Epub 2007 Feb 16.
3
The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.
Protein Sci. 2006 Apr;15(4):929-34. doi: 10.1110/ps.052064406.
4
YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol. 2005 Aug;187(15):5419-26. doi: 10.1128/JB.187.15.5419-5426.2005.
5
FFAS03: a server for profile--profile sequence alignments.
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W284-8. doi: 10.1093/nar/gki418.
6
A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts.
BMC Microbiol. 2005 Jun 14;5:35. doi: 10.1186/1471-2180-5-35.
7
Singular structures and operon organizations of essential two-component systems in species of Streptococcus.
Microbiology (Reading). 2004 Oct;150(Pt 10):3096-8. doi: 10.1099/mic.0.27550-0.
8
Refinement of macromolecular structures by the maximum-likelihood method.
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55. doi: 10.1107/S0907444996012255.
9
Methods used in the structure determination of bovine mitochondrial F1 ATPase.
Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):30-42. doi: 10.1107/S0907444995008754.
10
UCSF Chimera--a visualization system for exploratory research and analysis.
J Comput Chem. 2004 Oct;25(13):1605-12. doi: 10.1002/jcc.20084.
Zotero 插件