通过双向闭环复分解反应合成半短裸甲藻毒素B的稠合聚醚核心。
Synthesis of the fused polyether core of hemibrevetoxin B by two-directional ring-closing metathesis.
作者信息
Clark J Stephen, Grainger Damian M, Ehkirch Alexandra A-C, Blake Alexander J, Wilson Claire
机构信息
WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, United Kingdom.
出版信息
Org Lett. 2007 Mar 15;9(6):1033-6. doi: 10.1021/ol0630651. Epub 2007 Feb 21.
PMID:17311391
Abstract
The tetracyclic fused polyether core of the marine natural product hemibrevetoxin B has been prepared in an efficient manner by using a strategy in which ring-closing metathesis (RCM) reactions were employed for ring synthesis. Simultaneous construction of the A and D rings was accomplished by double two-directional RCM of a tetraene. [reaction: see text]
摘要
海洋天然产物半短裸甲藻毒素B的四环稠合聚醚核心已通过一种策略高效合成，该策略采用闭环复分解（RCM）反应进行环合成。通过四烯的双双向RCM实现了A环和D环的同时构建。[反应：见正文]
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