Miller M A, Pool R R, Coolman B R
Animal Disease Diagnostic Laboratory, Department of Veterinary Pathology, Purdue University, 406 S. University St., West Lafayette, IN 47907, USA.
Vet Pathol. 2007 Mar;44(2):240-3. doi: 10.1354/vp.44-2-240.
Synovial hemangioma was diagnosed in an 8-year-old castrated male Belgian Sheepdog with lameness of 3 months' duration. Pain, soft-tissue swelling, and hemarthrosis were localized to the left stifle joint. Projections of synovial membrane with reddish-purple nodules, excised via arthrotomy, were composed histologically of variably sized vascular channels that were lined by well-differentiated endothelial cells and separated by fibrous septa. Distension of some channels resulted in endothelial disruption, thrombosis, hemorrhage, necrosis, and focal spindle-cell proliferation. The limb was amputated to remove remaining neoplastic tissue. The hemangioma extended focally into the joint capsule and popliteal soft tissue but did not invade skeletal muscle or bone. The dog was free of detectable neoplasia 6 months after amputation. Synovial hemangioma is a rare benign vascular proliferation in people, most commonly in the knee, and should be included in the differential diagnosis for canine synovial tumors.
一只8岁去势雄性比利时牧羊犬被诊断为滑膜血管瘤,跛行3个月。疼痛、软组织肿胀和关节积血局限于左膝关节。通过关节切开术切除的滑膜上有红紫色结节,组织学上由大小不一的血管通道组成,这些通道内衬分化良好的内皮细胞,被纤维间隔分隔。一些通道扩张导致内皮破坏、血栓形成、出血、坏死和局灶性梭形细胞增殖。为切除残留的肿瘤组织,该肢体被截肢。血管瘤局部延伸至关节囊和腘窝软组织,但未侵犯骨骼肌或骨骼。截肢6个月后,该犬未发现可检测到的肿瘤。滑膜血管瘤在人类中是一种罕见的良性血管增生,最常见于膝关节,在犬滑膜肿瘤的鉴别诊断中应予以考虑。