剖析针对猿猴免疫缺陷病毒的体液免疫反应：抗体介导的病毒中和机制。
Dissecting the humoral immune response to simian immunodeficiency virus: mechanisms of antibody-mediated virus neutralization.
作者信息
Steckbeck Jonathan D, Cole Kelly Stefano
机构信息
Department of Medicine, Infectious Diseases Division, University of Pittsburgh School of Medicine, Pittsburgh PA 15261, USA.
出版信息
Immunol Res. 2006;36(1-3):51-60. doi: 10.1385/IR:36:1:51.
Abstract
The ultimate goal of an AIDS vaccine is to elicit potent cellular and humoral immune responses that will result in broadly enduring protective immunity. During the past several years, we have focused on characterizing the quantitative and qualitative properties of the antibody response, principally working to define the mechanism(s) of antibody-mediated neutralization in vitro. We have utilized a panel of monoclonal antibodies generated from monkeys infected with attenuated SIV for more than 8 mo to dissect the early events of virus infection involved in antibody-mediated neutralization. Presented herein are highlights from our studies that have identified potential mechanisms by which antibodies neutralize SIV in vitro.
摘要
艾滋病疫苗的最终目标是引发强大的细胞免疫和体液免疫反应，从而产生广泛持久的保护性免疫。在过去几年中，我们专注于表征抗体反应的定量和定性特性，主要致力于确定体外抗体介导中和作用的机制。我们利用了一组从感染减毒SIV超过8个月的猴子中产生的单克隆抗体，来剖析抗体介导中和作用中涉及的病毒感染早期事件。本文介绍了我们研究中的重点内容，这些研究确定了抗体在体外中和SIV的潜在机制。
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