房水的红外光谱检查
Infrared spectroscopic examination of aqueous humor.
作者信息
Weissbrodt David, Mueller Ralf, Perrin Jessica, Backhaus Juergen, Jonas Jost B
机构信息
Mannheim University of Applied Sciences, Institute for Instrumental Analysis, Mannheim, Germany.
出版信息
J Ocul Pharmacol Ther. 2007 Feb;23(1):54-6. doi: 10.1089/jop.2006.0051.
OBJECTIVE
The aim of this study was to report on a new technique for examining aqueous humor.
PARTICIPANTS
Aqueous humor samples obtained from 198 patients (cataract: n=66 eyes; age-related macular degeneration [AMD]: n=66; diabetic macular edema: n=66) were in vitro examined by mid infrared spectroscopy. After training and validating the technique, 66 samples were taken for the final independent prediction.
RESULTS
In computerized analysis of the spectrometric data, 22 (100%) cataract eyes were diagnosed as the cataract group, 17 (77%) diabetic macular edema eyes were diagnosed as the diabetic macular edema group, and 14 (64%) eyes with AMD were diagnosed as the AMD group. Mid infrared spectrometry could statistically significantly (P=0.004) differentiate between the 3 study groups.
CONCLUSIONS
Mid infrared spectroscopic examination of aqueous humor may be able to differentiate eyes with cataract, AMD, or diabetic macular edema.
目的
本研究旨在报告一种检查房水的新技术。
参与者
从198例患者中获取的房水样本（白内障：66只眼；年龄相关性黄斑变性[AMD]：66例；糖尿病性黄斑水肿：66例）通过中红外光谱进行体外检查。在对该技术进行培训和验证后，选取66个样本进行最终的独立预测。
结果
在光谱数据的计算机分析中，22只（100%）白内障眼被诊断为白内障组，17只（77%）糖尿病性黄斑水肿眼被诊断为糖尿病性黄斑水肿组，14只（64%）AMD眼被诊断为AMD组。中红外光谱法在统计学上能显著（P=0.004）区分这3个研究组。
结论
房水的中红外光谱检查可能能够区分白内障、AMD或糖尿病性黄斑水肿的眼睛。
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