Bidel S, Silventoinen K, Hu G, Lee D-H, Kaprio J, Tuomilehto J
Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland.
Eur J Clin Nutr. 2008 Feb;62(2):178-85. doi: 10.1038/sj.ejcn.1602712. Epub 2007 Mar 7.
To study the joint association of coffee consumption and serum gamma-glutamyltransferase (GGT) levels on the risk of developing type II diabetes.
DESIGN, SETTING AND SUBJECTS: A total of 21,826 Finnish men and women who were 35-74 years of age and without any history of diabetes at baseline (years 1982, 1987, 1992 and 1997) were included in the present analyses. They were prospectively followed up for onset of type II diabetes (n=862 cases), death or until the end of the year 2002. Coffee consumption, serum GGT and other study parameters were determined at baseline using standardized measurements. Analyses were stratified by the serum GGT level classified into two classes using the 75th sex-specific percentiles as the cut point.
Coffee consumption was significantly and inversely associated with incident diabetes among both men and women. Serum GGT modified the association between coffee consumption and incident diabetes. Subjects in the high category of coffee consumption with the GGT level > or = 75th percentile showed a significant inverse association for women, and for both sexes combined. The association was not significant in subjects with the GGT level < or = 75th percentile. There was a significant interaction effect of GGT and coffee consumption on risk of type II diabetes in data of women (P=0.05) and in both sexes combined (P=0.02).
Habitual coffee consumption is associated with lower incidence of type II diabetes particularly in those with higher baseline serum GGT levels.
研究咖啡摄入量与血清γ-谷氨酰转移酶（GGT）水平联合作用对II型糖尿病发病风险的影响。
设计、研究地点与研究对象：本分析纳入了总共21826名年龄在35 - 74岁之间、基线时（1982年、1987年、1992年和1997年）无糖尿病病史的芬兰男性和女性。对他们进行前瞻性随访，观察II型糖尿病发病情况（n = 862例）、死亡情况或直至2002年底。在基线时采用标准化测量方法测定咖啡摄入量、血清GGT及其他研究参数。分析按血清GGT水平分层，以性别特异性第75百分位数作为切点分为两类。
男性和女性中，咖啡摄入量与糖尿病发病均呈显著负相关。血清GGT改变了咖啡摄入量与糖尿病发病之间的关联。对于女性以及男女合并数据，GGT水平高于或等于第75百分位数的高咖啡摄入量组受试者呈现显著负相关。在GGT水平低于或等于第75百分位数的受试者中，该关联不显著。在女性数据（P = 0.05）和男女合并数据（P = 0.02）中，GGT与咖啡摄入量对II型糖尿病风险存在显著交互作用。
习惯性咖啡摄入与II型糖尿病较低发病率相关，尤其在基线血清GGT水平较高的人群中。
