Vatten Lars J, Eskild Anne, Nilsen Tom I L, Jeansson Stig, Jenum Pål A, Staff Anne Cathrine
Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Am J Obstet Gynecol. 2007 Mar;196(3):239.e1-6. doi: 10.1016/j.ajog.2006.10.909.
This study was undertaken to assess changes in placenta growth factor and soluble fms-like tyrosine kinase-1 as predictors of preeclampsia.
Nested case-control study of 154 preeclampsia cases delivered preterm and 190 delivered at term, and 392 controls.
Comparing the lowest and highest quartile of placenta growth factor increase from first to second trimester, the odds for preterm preeclampsia was 13.8 (95% CI, 4.4-43.2) higher for women with the lowest increase. Compared with controls, women with preterm preeclampsia had lower soluble fms-like tyrosine kinase-1 in the first, but higher in second trimester. Comparing highest and lowest quartile of increase, the odds for preterm preeclampsia was 9.2 (95% CI 3.4-25.0) higher for women with highest increase. Low placenta growth factor and high soluble fms-like tyrosine kinase-1 increase combined yielded extremely high relative risk of preterm preeclampsia (odds ratio, 35.3, 95% CI, 7.6-164.2), compared with the combination of high (placenta growth factor) and low (soluble fms-like tyrosine kinase-1) increase.
Low placenta growth factor and high soluble fms-like tyrosine kinase-1 increase from first to second trimester are strong predictors of preeclampsia.
本研究旨在评估胎盘生长因子和可溶性fms样酪氨酸激酶-1的变化作为子痫前期的预测指标。
对154例早产的子痫前期病例、190例足月分娩的病例以及392例对照进行巢式病例对照研究。
比较孕早期至孕中期胎盘生长因子增加量的最低四分位数和最高四分位数，胎盘生长因子增加量最低的女性发生早产子痫前期的几率高13.8倍（95%可信区间，4.4 - 43.2）。与对照组相比，早产子痫前期女性在孕早期的可溶性fms样酪氨酸激酶-1水平较低，但在孕中期较高。比较增加量的最高四分位数和最低四分位数，增加量最高的女性发生早产子痫前期的几率高9.2倍（95%可信区间3.4 - 25.0）。与胎盘生长因子增加量高而可溶性fms样酪氨酸激酶-1增加量低的组合相比，胎盘生长因子低且可溶性fms样酪氨酸激酶-1增加量高的组合导致早产子痫前期的相对风险极高（优势比，35.3，95%可信区间，7.6 - 164.2）。
孕早期至孕中期胎盘生长因子低且可溶性fms样酪氨酸激酶-1增加量高是子痫前期的有力预测指标。
Zotero 插件