[欧洲赤松针叶中二萜类化合物的研究]
[Studies on diterpenes in needles of Pinus sylvestris].
作者信息
Zhang Rong, Duan Hong-quan, Yao Zhi, Pan Qin, Zhang Fu-geng
机构信息
The School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2006 Dec;31(23):1956-9.
OBJECTIVE
To research the constituents in needles of Pinus sylvestris.
METHOD
Repeated column chromatography and preparation HPLC are used for compound isolation, and their structures were elucidated on the basis of spectral data analysis.
RESULT
Six compounds, pinifolic acid (1), 15-oxo-8 (17) -labden-18-oic acid (2) , 15-acetoxy-labd-8 ( 17)-en-18-oic acid (3), dehydroabietic acid (4), 7alpha-hydroxydehydroabietic acid (5), 7beta-hydroxydehydroabietic acid (6) were isolated from the needles of P. sylvestris.
CONCLUSION
Compound 3-6 were isolated from the needles of P. sylvestris for the first time, and compound 3 is a new natural product. The petroleum ether and EtOAc extracts showed significant cytotoxic effects to Hela and A549. Compounds 2, 4-6 revealed a positive distinction compared to the control group.
目的
研究樟子松针叶中的成分。
方法
采用反复柱色谱法和制备型高效液相色谱法进行化合物分离，并根据光谱数据分析阐明其结构。
结果
从樟子松针叶中分离出6种化合物，分别为松叶酸（1）、15-氧代-8（17）-赖百当-18-酸（2）、15-乙酰氧基-赖百当-8（17）-烯-18-酸（3）、去氢枞酸（4）、7α-羟基去氢枞酸（5）、7β-羟基去氢枞酸（6）。
结论
化合物3 - 6首次从樟子松针叶中分离得到，化合物3为新天然产物。石油醚和乙酸乙酯提取物对Hela和A549显示出显著的细胞毒性作用。化合物2、4 - 6与对照组相比有阳性差异。
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