聚焦工程相干反斯托克斯拉曼散射显微镜：数值研究

Focus-engineered coherent anti-Stokes Raman scattering microscopy: a numerical investigation.

作者信息

Krishnamachari Vishnu Vardhan, Potma Eric Olaf

机构信息

Department of Chemistry and Beckman Laser Institute, University of California at Irvine, Irvine, California 92697, USA.

出版信息

J Opt Soc Am A Opt Image Sci Vis. 2007 Apr;24(4):1138-47. doi: 10.1364/josaa.24.001138.

DOI:10.1364/josaa.24.001138

PMID:17361301

Abstract

The coherent anti-Stokes Raman scattering (CARS) signal is calculated as a function of focal-field distributions with engineered phase jumps. We show that the focal fields in CARS microscopy can be shaped such that the signal from the bulk is suppressed in the forward detection mode. We present the field distributions that display enhanced sensitivity to vibrationally resonant object interfaces in the lateral dimension. The use of focus-engineered CARS provides a simple means to detect chemical edges against the strong background signals from the bulk.

摘要

相干反斯托克斯拉曼散射（CARS）信号是作为具有工程化相位跃变的焦场分布的函数来计算的。我们表明，CARS显微镜中的焦场可以被塑造，使得在正向检测模式下来自样品主体的信号被抑制。我们展示了在横向维度上对振动共振物体界面具有增强灵敏度的场分布。使用聚焦工程化的CARS提供了一种简单的方法来在来自样品主体的强背景信号中检测化学边缘。