人类睡眠的生物钟学
Chronobiology of sleep in humans.
作者信息
Lack L C, Wright H R
机构信息
School of Psychology, Flinders University, Adelaide, South Australia, Australia.
出版信息
Cell Mol Life Sci. 2007 May;64(10):1205-15. doi: 10.1007/s00018-007-6531-2.
Periodic circadian (24-h) cycles play an important role in daily hormonal and behavioural rhythms. Usually our sleep/wake cycle, temperature and melatonin rhythms are internally synchronized with a stable phase relationship. When there is a desynchrony between the sleep/wake cycle and circadian rhythm, sleep disorders such as advanced and delayed sleep phase syndrome can arise as well as transient chronobiologic disturbances, for example from jet lag and shift work. Appropriately timed bright light is effective in re-timing the circadian rhythm and sleep pattern to a more desired time, ameliorating these disturbances. Other less potent retiming effects may also be obtained from the judicious use of melatonin and exercise.
周期性昼夜节律（24小时）在日常激素和行为节律中起着重要作用。通常，我们的睡眠/清醒周期、体温和褪黑素节律通过稳定的相位关系在内部实现同步。当睡眠/清醒周期与昼夜节律之间出现不同步时，可能会出现诸如早睡相位综合征和晚睡相位综合征等睡眠障碍，以及短暂的生物钟紊乱，例如时差反应和轮班工作导致的紊乱。适时的强光照射能有效地将昼夜节律和睡眠模式重新调整到更理想的时间，改善这些紊乱情况。通过合理使用褪黑素和进行锻炼，也可能获得其他较弱的重新调整效果。
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