Chiou C-C, Wang P-N, Yang L-C, Kuo T-T, Hong H-S
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
J Eur Acad Dermatol Venereol. 2007 Apr;21(4):532-5. doi: 10.1111/j.1468-3083.2006.02013.x.
Xanthogranuloma (XG) is rarely observed in adults and has been reported to be associated with chronic myelogenous leukaemia (CML) and/or neurofibromatosis type 1 (NF1). A 68-year-old woman with adult T-cell leukaemia/lymphoma (ATLL) gradually developed disseminated XGs over the 3 years since disease onset. Histopathological examination of a skin biopsy revealed the presence of histiocytes in the dermis with a few Touton giant cells admixed with lymphoid cells. The lesions of XGs persisted despite chemotherapy with prednisolone and chlorambucil for her ATLL. This is the first report of disseminated XGs associated with ATLL. The association of disseminated XGs with haematologic malignancies was reviewed and the possible pathogenesis of this association will be discussed.
黄色肉芽肿（XG）在成人中很少见，据报道与慢性粒细胞白血病（CML）和/或1型神经纤维瘤病（NF1）有关。一名68岁患有成人T细胞白血病/淋巴瘤（ATLL）的女性自疾病发作以来的3年中逐渐出现播散性XG。皮肤活检的组织病理学检查显示真皮中有组织细胞，并有一些图顿巨细胞与淋巴细胞混合。尽管对她的ATLL使用泼尼松龙和苯丁酸氮芥进行了化疗，但XG病变仍持续存在。这是第一例与ATLL相关的播散性XG报告。本文回顾了播散性XG与血液系统恶性肿瘤的关联，并将讨论这种关联的可能发病机制。
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